Evidence map›Paper›PMID 41008953›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Yun-Dan Guo, Ming-Xuan Zhang, Quan-Yong Yu, Lu-Lu Wang, Yan-Xing Han, Tian-Le Gao, Yuan Lin, Cai Tie, Jian-Dong Jiang

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. StudyingPharmaceuticals (Basel, Switzerland) · 2025
    Review
  3. Cuspidatyl Ferulate, a Novel Phenolic Acid fromAntioxidants (Basel, Switzerland) · 2025
    Article
  4. Special Issue "Natural Products in Drug Discovery and Development".International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yun-Dan GuoInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Ming-Xuan ZhangInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Quan-Yong YuSchool of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Lu-Lu WangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yan-Xing HanInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.ORCID 0000-0003-0073-4357
Tian-Le GaoInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yuan LinInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Cai TieState Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources & School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China.
Jian-Dong JiangInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Funding

CAMS Innovation Fund for Medical Sciences 2024-I2M-ZH-012, 2022-I2M-1-016Key Project Fund of the Chinese Academy of Engineering Organized Scientific Research Strategy Study on Anti-Infective Drugs for Emerging Infectious Diseases, 2025-XZ-125National Natural Science Foundation of China 82374061
6 · The paper itself

Abstract

background and purposeVulvovaginal candidiasis (VVC), caused by

methodsGC-MS identified SXC's major bioactive components, while broth microdilution assays determined minimum inhibitory concentrations (MICs) against bacterial/fungal pathogens, and synergistic interactions with amphotericin B (AmB) or fluconazole (FLC) were assessed via time-kill kinetics. Anti-biofilm activity was quantified using crystal violet/XTT assays, and in vitro studies evaluated SXC's effects on

resultsGas chromatography-mass spectrometry identified 10 key volatile components contributing to SXC's activity. SXC exhibited broad-spectrum antimicrobial activity with MIC values ranging from 0.125-16 μL/mL against bacterial and fungal pathogens, including fluconazole-resistant Candida strains. Time-kill assays revealed that combinations of AmB-SXC and FLC-SXC achieved sustained synergistic bactericidal activity across all tested strains. Mechanistic studies revealed SXC's dual antifungal actions: inhibition of

conclusionsSXC shows promise as a broad-spectrum natural antimicrobial against fungal pathogens. It inhibited

Indexed as

biofilmCandida albicansoxidant stressriboflavinvolatile extracts of Hyssopus cuspidatus Borissvulvovaginal candidiasis

Identifiers

PMID41008953
PMCPMC12466673

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.