ReviewCancers2025
Exploring the Oncogenic Potential of Human Papillomavirus in Subungual and Plantar Squamous Cell Carcinoma: A Review of the Literature.
Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSquamous cell carcinoma (SCC) of the nail unit, known as the subungual region, and of the plantar foot is rare but often misdiagnosed due to its similar appearance to verruca, a common wart. The delayed diagnosis and treatment of SCC in the subungual and plantar foot leads to poorer outcomes. Human papillomavirus (HPV), and specifically the oncogenic potential of particular strains, influences SCC pathogenesis, progression, and treatment response.
methodsThis review aims to address the current state of knowledge as well as deficits associated with clinical treatment of SCC in two anatomically challenging locations: verrucous carcinoma (VC), a variant of SCC that affects the plantar foot, and subungual SCC. Articles reviewed were evaluated based on date of publication, quality, and originality. Additionally, articles published after 2015 were given preferential consideration.
resultsThis review highlights considerations to reduce diagnostic delays and improve patient outcomes when considering two uncommon cutaneous malignancies.
conclusionsWe recognize that misdiagnosis poses a barrier in the treatment of both plantar VC and subungual SCC. As such, we identify pertinent clinical pearls to assist in accurate identification and treatment of SCC in these locations. Lastly, we address the role of HPV and the microbiome in the pathogenesis of SCC to improve treatment efficacy.
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