Evidence map›Paper›PMID 41008850›Full record

ArticleCancers2025

Presence of Adipophilin-Positive Cancer-Associated Fibroblasts Is an Independent Poor Prognostic Indicator and Is Correlated with Immature-Type Desmoplastic Reaction in Patients with Colorectal Cancer.

Toshinori Kobayashi, Mitsuaki Ishida, Hiroki Uehara, Shoichiro I, Norikazu Yamada, Yuto Igarashi, Chie Hagiwara, Yoshihiro Mori, Yoshinobu Hirose, Jun Watanabe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Toshinori KobayashiDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata 573-1010, Japan.ORCID 0000-0001-8042-5073
Mitsuaki IshidaDepartment of Pathology, Osaka Medical and Pharmaceutical University, 2-7, Daigaku-machi, Takatsuki 569-8686, Japan.
Hiroki UeharaDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata 573-1010, Japan.
Shoichiro IDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata 573-1010, Japan.
Norikazu YamadaDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata 573-1010, Japan.
Yuto IgarashiDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata 573-1010, Japan.
Chie HagiwaraDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata 573-1010, Japan.
Yoshihiro MoriDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata 573-1010, Japan.
Yoshinobu HiroseDepartment of Pathology, Osaka Medical and Pharmaceutical University, 2-7, Daigaku-machi, Takatsuki 569-8686, Japan.
Jun WatanabeDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata 573-1010, Japan.

Funding

Japan Society for the Promotion of Science JP23K15509; JP22K06948; JP25K10291Osaka Community Foundation 2023
6 · The paper itself

Abstract

BACKGROUND/

objectivesImmature-type (IM type) desmoplastic reaction (DR) is a poor prognostic indicator of CRC; however, the underlying mechanism has not yet been clarified. Recent studies have demonstrated that energy metabolism, including lipid metabolism, in cancer-associated fibroblasts (CAFs) can critically impact cancer cell growth. The prognostic significance of lipid-laden CAFs in CRC has not yet been elucidated. This study aimed to clarify whether the presence of lipid-laden CAFs correlates with the DR type and prognosis in CRC.

methodsWe enrolled patients with pT3 or pT4 CRC who underwent surgical resection without neoadjuvant chemoradiotherapy. Immunohistochemical staining for adipophilin (ADP) was performed to determine the presence of lipid-laden CAFs.

resultsThe cohort included 70 patients (49 men and 21 women) with a median age of 74 years. ADP-positive lipid-laden CAFs were observed in 37 patients (53%). The presence of lipid-laden CAFs and ADP expression in carcinoma cells at the invasive front was significantly correlated with IM-type DR (

conclusionsThese results suggest that the presence of lipid-laden CAFs enhance cancer progression, invasion, and metastasis, and that IM-type DR might be related to the lipid-rich tumor microenvironment.

Indexed as

cancer-associated fibroblastscolorectal cancerdesmoplastic reactionlipid-laden cancer-associated fibroblastslipid metabolism

Identifiers

PMID41008850
PMCPMC12468228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.