ReviewCancers2025
The Role of Tumor-Infiltrating B Lymphocytes in Colorectal Cancer Patients: A Systematic Review of Immune Landscape Evolution.
Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have found that the presence and density of tumor-infiltrating T lymphocytes has significant prognostic value in colon and rectal cancer. However, there is a paucity of systematic reviews focusing on the role of tumor-infiltrating B lymphocytes (TIBLs) in colorectal cancer. The aim of this review was to assess the role of all known subsets of TIBLs implicated in colorectal cancer, as well as to identify the methodologies used for the identification of TIBLs and establish their prognostic value in the colorectal tumor microenvironment (TME).
methodsA systematic literature search was conducted from 2000 to 2025 using the PubMed (Medline), Embase and Cochrane Library databases. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were followed to identify eligible studies.
resultsA total of 32 original papers involving 5766 individual patients met the inclusion criteria. Several B cell types in the immune TME of colon and rectal cancer were identified, each with specific roles and prognostic value. Several distinct methodologies were used for the identification of these cells, according to specific detection protocols used by various institutions. Certain immunological pathways through which these cells may be involved in the carcinogenesis of colorectal tumors have also been identified, which may potentially lead to the development of novel immunotherapy targets.
conclusionsWe concluded that TIBLs play a significant role in the immune microenvironment of colorectal cancer, providing theoretical evidence for potential biomarkers which may constitute a valuable target for individualized treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.