Evidence map›Paper›PMID 41008809›Full record

ArticleCancers2025

Insight into the Wnt Pathway in Sporadic Small Bowel Adenocarcinoma.

Takayoshi Nishimoto, Atsushi Tatsuguchi, Takeshi Yamada, Sho Kuriyama, Aitoshi Hoshimoto, Jun Omori, Naohiko Akimoto, Katya Gudis, Keigo Mitsui, Shu Tanaka and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Takayoshi NishimotoDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.
Atsushi TatsuguchiDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.ORCID 0000-0002-8499-8837
Takeshi YamadaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo 113-8603, Japan.ORCID 0000-0002-1436-7482
Sho KuriyamaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo 113-8603, Japan.ORCID 0000-0001-7055-8032
Aitoshi HoshimotoDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.
Jun OmoriDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.
Naohiko AkimotoDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.ORCID 0000-0001-9880-4143
Katya GudisDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.
Keigo MitsuiDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.
Shu TanakaDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.ORCID 0000-0003-4121-5553
Shunji FujimoriDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.
Tsutomu HatoriDepartment of Pathology, Nippon Medical School, Chiba Hokusoh Hospital, 1715 Kamagari, Inzai 270-1694, Chiba, Japan.
Akira ShimizuDepartment of Analytic Human Pathology, Nippon Medical School, Tokyo 113-8602, Japan.ORCID 0000-0002-4364-9251
Masanori AtsukawaDepartment of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe Wnt signaling pathway is pivotal in the adenoma-carcinoma sequence; however, its role in small bowel adenocarcinoma (SBA) remains insufficiently characterized. We analyzed the clinicopathological significance of Wnt pathway-related gene mutations and the expression of downstream or associated proteins in SBA.

methodsImmunohistochemical staining for β-catenin, cyclin D1, c-Myc, E-cadherin, and Wnt5a was performed in 75 primary SBA surgical specimens. Targeted next-generation sequencing was conducted in 48 of these cases.

resultsThe genomic alterations in the Wnt pathway were identified as

conclusionsThese findings suggest that both canonical and noncanonical Wnt pathway-related proteins are involved in SBA carcinogenesis and progression. Notably, the canonical Wnt pathway appears to play a predominant role in intestinal-type SBA.

Indexed as

APC mutationgenomic profilesmall bowel adenocarcinomaWnt5aWnt pathwayβ-catenin

Identifiers

PMID41008809
PMCPMC12468334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.