ArticleBiomolecules2025
Postmortem Stability Analysis of Lipids and Polar Metabolites in Human, Rat, and Mouse Brains.
Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Temporal and spatial RNA expression dynamics in postmortem skin support PMI estimation and reveal spatial signatures of antemortem injury.International journal of legal medicine · 2026Article
- Sequential Penta-Omic Extraction Method Using Single Biospecimens of Post-mortem Human Brain.bioRxiv : the preprint server for biology · 2026Article
- Dynamics of Postmortem Gene Expression in Normal and Neoplastic Murine Liver.Life (Basel, Switzerland) · 2026Article
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Authors and funding
12 authors.
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Abstract
Lipids and polar metabolites are emerging as promising indicators of the brain's molecular phenotype in both clinical and fundamental research. However, the impact of postmortem delay on these compounds, unavoidable in human brain studies, remains insufficiently understood. In this study, we examined the postmortem stability of lipids and polar metabolites over a 48-h interval in the brains of three species: humans, rats, and mice. We show that the abundance levels of 23% of the 867 studied lipids and 75% of the 104 studied polar metabolites were affected significantly by postmortem delay in at least one species. The postmortem effects correlated positively and significantly among the species, while showing an approximately tenfold slower rate in humans compared to rodents. The only exception to the postmortem rates deceleration was a group of oxidized fatty acids, which accumulated at similar speed in both humans and rodents. These findings provide valuable insights for improving reproducibility and refining the interpretation of human and rodent brain lipidome and metabolome data in future studies.
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