Evidence map›Paper›PMID 41008574›Full record

ArticleBiomolecules2025

PPARγ Agonism Modulates Synovial Macrophage and Cartilage Responses in an Equine Model of Synovial Inflammation-Implications for Joint Therapy.

Slàine F Chaimbeul, Nubia N P Rodrigues, Danny D Thurston, Kirsten E Scoggin, Jennifer Janes, Cale A Jacobs, James N MacLeod, Austin V Stone, Bruno C Menarim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Slàine F ChaimbeulDepartment of Veterinary Clinical Sciences, University of Copenhagen, 2630 Taastrup, Denmark.ORCID 0009-0002-6875-4055
Nubia N P RodriguesFaculdade de Medicina Veterinária e Zootecnia, Universidade São Paulo, São Paulo 05508-270, SP, Brazil.ORCID 0000-0002-5156-8128
Danny D ThurstonRood and Riddle Equine Hospital, Saratoga, NY 12866, USA.ORCID 0009-0006-7720-3617
Kirsten E ScogginGluck Equine Research Center, Department of Veterinary Sciences, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0003-1348-641X
Jennifer JanesVeterinary Diagnostic Laboratory, Department of Veterinary Sciences, University of Kentucky, Lexington, KY 40506, USA.
Cale A JacobsDepartment of Orthopedic Surgery, College of Medicine, Harvard University, Boston, MA 02138, USA.
James N MacLeodGluck Equine Research Center, Department of Veterinary Sciences, University of Kentucky, Lexington, KY 40506, USA.
Austin V StoneDepartment of Orthopedic Surgery, College of Medicine, University of Kentucky, Lexington, KY 40506, USA.
Bruno C MenarimGluck Equine Research Center, Department of Veterinary Sciences, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0003-1829-4978

Funding

Town & Country Farms in Lexington, KY and the Osteoarthritis Alliance of Kentucky N/A
6 · The paper itself

Abstract

Synovitis resolution is critical for joint homeostasis and prevents the progression of osteoarthritis (OA). Treatments like NSAIDs and intra-articular corticosteroids relieve symptoms by blocking pro-inflammatory mediators, but also impair the production of pro-resolving mediators, contributing to the likelihood of chronic synovitis. PPARγ signaling is an essential mechanism of synovitis resolution, which is decreased in OA tissues. To evaluate the potential of PPARγ agonists to promote pro-resolving pathways, equine macrophages cultured in autologous, normal, or inflamed synovial fluid (

Indexed as

CartilageMacrophagesPPAR gammaSynovitisAcyclic MonoterpenesAnimalsCartilage, ArticularDisease Models, AnimalHorsesInflammationOsteoarthritisPioglitazoneSynovial FluidSynovial MembraneAcyclic MonoterpenesgeraniolPioglitazonePPAR gammainflammation resolutionjoint diseaseosteoarthritistreatment

Identifiers

PMID41008574
PMCPMC12467806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.