Evidence map›Paper›PMID 41008550›Full record

ArticleBiomolecules2025

CD45 and Basigin (CD147) Are Functional Ligands for Galectin-8 on Human Leukocytes.

Jean-Philippe F Gourdine, Porfirio Nava, Alexander J Noll, Duc M Duong, Nicholas T Seyfried, Richard D Cummings

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jean-Philippe F GourdineChemistry Department, Lewis & Clark College, Portland, OR 97219, USA.ORCID 0000-0001-9969-8610
Porfirio NavaDepartment of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Mexico City 07360, Mexico.ORCID 0000-0002-0506-1510
Alexander J NollThe Emmes Company, LLC, Rockville, MD 20850, USA.
Duc M DuongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30329, USA.
Nicholas T SeyfriedDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0002-4507-624X
Richard D CummingsDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Funding

Protein-glycan Interactions in the Vascular SystemP01HL085607 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI CUMMINGS, RICHARD D, MCEVER, RODGER PAUL · 2006 to 2015
$16.8M
ENNCF - Viral Vector CoreP30NS055077 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2008 to 2018
$6.8M
NHLBI NIH HHS P01 HL085607NIH HHS 1P41HL085607-09NINDS NIH HHS P30 NS055077
6 · The paper itself

Abstract

The interactions of leukocyte glycoproteins with adhesion and signaling molecules through glycan recognition are not well understood. We previously demonstrated that galectin-8, a tandem-repeat lectin with N- and C-terminal carbohydrate binding domains which is highly expressed in endothelial and epithelial cells, can bind to activated neutrophils to induce surface exposure of phosphatidylserine (PS) without DNA fragmentation or apoptosis, in a process termed

Indexed as

BasiginGalectinsLeukocyte Common AntigensLeukocytesHL-60 CellsHumansLigandsProtein BindingBasiginGalectinsLeukocyte Common AntigensLGALS8 protein, humanLigandsPTPRC protein, humanbasiginCD45galectin-8glycan ligandsleukocytes

Identifiers

PMID41008550
PMCPMC12467718

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.