Evidence map›Paper›PMID 41008529›Full record

ArticleBiomolecules2025

Metabolic Interactions of Side-chain Extended and Unsaturated Vitamin D Analogs with Cytochrome P450 Enzymes: Integrating Theoretical and Experimental Approaches.

Teresa Żołek, Mayur Kadam, Sharmin Nadkarni, Kaori Yasuda, Michał Chodyński, Krzysztof Krajewski, Olga Michalak, Joanna Tobiasz, Marek Kubiszewski, Toshiyuki Sakaki and 1 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Teresa ŻołekDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha, 02-097 Warsaw, Poland.ORCID 0000-0002-6781-0329
Mayur KadamDepartment of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha, 02-097 Warsaw, Poland.ORCID 0009-0004-8686-7648
Sharmin NadkarniDepartment of Chemistry, Sant Rawool Maharaj Mahavidyalaya S. N. Desai Chowk, Udyamnagar, Kudal, Sindhudurg, Maharashtra 416520, India.
Kaori YasudaDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Toyama 939-0398, Japan.
Michał ChodyńskiChemistry Section, Research Group of Pharmacy, Cosmetic Chemistry and Biotechnology, Łukaszewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera, 01-793 Warsaw, Poland.
Krzysztof KrajewskiChemistry Section, Research Group of Pharmacy, Cosmetic Chemistry and Biotechnology, Łukaszewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera, 01-793 Warsaw, Poland.
Olga MichalakChemistry Section, Research Group of Pharmacy, Cosmetic Chemistry and Biotechnology, Łukaszewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera, 01-793 Warsaw, Poland.ORCID 0000-0002-1067-4223
Joanna TobiaszChemistry Section, Research Group of Pharmacy, Cosmetic Chemistry and Biotechnology, Łukaszewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera, 01-793 Warsaw, Poland.
Marek KubiszewskiChemistry Section, Research Group of Pharmacy, Cosmetic Chemistry and Biotechnology, Łukaszewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera, 01-793 Warsaw, Poland.
Toshiyuki SakakiDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Toyama 939-0398, Japan.ORCID 0000-0001-7064-8185
Andrzej KutnerDepartment of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha, 02-097 Warsaw, Poland.ORCID 0000-0002-9518-4142

Funding

Horizon - the Framework Programme for Research and Innovation (2022-2027), Marie Skłodowska-Curie Actions, of the European Union under Research Executive Agency 101119427
6 · The paper itself

Abstract

The clinical use of 1,25-dihydroxycholecalciferol (1,25D3), the active form of vitamin D

Indexed as

Cytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemVitamin DVitamin D3 24-HydroxylaseHumansMolecular Docking SimulationCYP24A1 protein, humanCYP3A4 protein, humanCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemVitamin DVitamin D3 24-Hydroxylasecomputational modelingcytochrome CYP24A1cytochrome CYP3A4PRI-1906PRI-1927PRI-1937PRI-1938vitamin D analog

Identifiers

PMID41008529
PMCPMC12467546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.