ReviewBiomolecules2025
The Dual Role of Macrophage Extracellular Traps in Host Defense and Disease: Mechanisms and Therapeutic Implications.
Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Review
- Review
- Traffic and functional polarization of macrophages in the areas of programmed interdigital cell death in the embryonic chick.Apoptosis : an international journal on programmed cell death · 2026Article
- PTGDS is a potential marker for lung adenocarcinoma identified in a pancancer analysis.Scientific reports · 2026Article
- Predictive value of the C-reactive protein-to-lymphocyte ratio for prognosis in heart failure patients with acute kidney injury.Frontiers in physiology · 2026Article
- Elevated neutrophil extracellular traps formation driven by the HPV-mediated CXCL8-CXCR1/2-ROS-p21 axis promotes the growth and metastasis of cervical cancer.Frontiers in immunology · 2026Article
- Targeting Macrophage-Mediated Mechanisms in Sepsis-Induced Cardiomyopathy: From Pathophysiology to Therapeutic Strategies.Journal of inflammation research · 2026Review
- Neutrophil Extracellular Traps in Pediatric Infections: A Systematic Review.Current issues in molecular biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Macrophage extracellular traps (METs), which are extracellular immune structures released by macrophages, consist primarily of double-stranded DNA, histones, elastase, matrix metalloproteinase, myeloperoxidase, and other components. Recent studies have found that various pathogens (such as bacteria, fungi, and parasites) and environmental pollutants could induce the formation of METs through different mechanisms to help the host resist infection. However, accumulating evidence suggests that METs play a double-edged role in immune response, enhancing host defense while potentially contributing to tissue damage under certain pathological conditions. This review summarizes the mechanisms underlying the formation of METs, including different pathways triggered by various pathogens and environmental pollutants. We also discussed the role of METs in respiratory diseases, autoimmune diseases, metabolic diseases, tumors, and transplantation and injury, as well as recent advances in MET-targeted drugs, aiming to provide new insights for improving treatment strategies of relevant diseases.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.