Evidence map›Paper›PMID 41008368›Full record

ArticleBrain sciences2025

Sex-Specific Association Between XPC rs2228001 Polymorphism and Parkinson's Disease Risk in a Mexican Population: A Case-Control Study Exploring Gene-Environment Interactions.

Karla Mariana Alvarado-Retana, Daniel Francisco Ramos-Rosales, Elizabeth Irasema Antuna-Salcido, Sergio Manuel Salas-Pacheco, Francisco Xavier Castellanos-Juárez, Edna Madai Méndez-Hernández, Alma Cristina Salas-Leal, Osmel La Llave-León, Gerardo Quiñones-Canales, Oscar Arias-Carrión and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karla Mariana Alvarado-RetanaInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico.
Daniel Francisco Ramos-RosalesInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico.ORCID 0000-0003-4109-267X
Elizabeth Irasema Antuna-SalcidoInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico.
Sergio Manuel Salas-PachecoFacultad de Odontología, Universidad Juárez del Estado de Durango, Durango 34070, Mexico.ORCID 0000-0001-7123-8751
Francisco Xavier Castellanos-JuárezInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico.ORCID 0000-0002-5570-3817
Edna Madai Méndez-HernándezInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico.
Alma Cristina Salas-LealInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico.
Osmel La Llave-LeónInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico.ORCID 0000-0003-2788-3344
Gerardo Quiñones-CanalesHospital Santiago Ramón y Cajal-ISSSTE, Durango 34070, Mexico.
Oscar Arias-CarriónDivisión de Neurociencias, Clínica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México 14389, Mexico.ORCID 0000-0002-9982-7571
Ada Sandoval-CarrilloInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico.
José Manuel Salas-PachecoInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico.

Funding

CONSEJO DE CIENCIA Y TECNOLOGIA DEL ESTADO DE DURANGO F-101
6 · The paper itself

Abstract

BACKGROUND/

objectivesEmerging evidence implicates impaired DNA repair mechanisms in the pathogenesis of Parkinson's disease (PD), particularly in the context of oxidative stress and environmental exposures. This study investigated the association between five polymorphisms in nucleotide excision repair (NER) pathway genes and PD susceptibility in a northern Mexican mestizo population.

methodsWe conducted a case-control study including 137 patients with clinically diagnosed PD and 137 age- and sex-matched controls. Genomic DNA was isolated from peripheral blood, and genotyping of

resultsA significantly higher prevalence of pesticide exposure was observed in PD patients than in controls (OR 2.08, 95% CI 1.18-3.68;

conclusionsOur findings suggest a sex-specific genetic contribution to PD susceptibility involving the

Indexed as

nucleotide excision repairParkinson’s diseasers2228001XPC

Identifiers

PMID41008368
PMCPMC12468217

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.