Evidence map›Paper›PMID 41008365›Full record

ArticleBrain sciences2025

Spinal Cord Injury in Real Time: Intra-Operative Ultrasound for Acute Phase Examination in Non-Human Primates.

Eleni Sinopoulou, Michelle W Chow, Numaira Obaid, Emily Chong, Yvette S Nout-Lomas, Rachele Wurr, Ryan Macon, J Russell Huie, Adam R Ferguson, Mark H Tuszynski and 3 more

Abstract read
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In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eleni SinopoulouDepartment of Neurosciences, University of California-San Diego, La Jolla, CA 92093, USA.
Michelle W ChowDepartment of Neurosciences, University of California-San Diego, La Jolla, CA 92093, USA.ORCID 0009-0009-8743-7179
Numaira ObaidMechatronic Systems Engineering, Simon Fraser University, Surrey, BC V3TOA3, Canada.
Emily ChongDepartment of Neurosciences, University of California-San Diego, La Jolla, CA 92093, USA.
Yvette S Nout-LomasCollege of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80521, USA.ORCID 0000-0001-6583-2308
Rachele WurrCalifornia National Primate Research Center, University of California, Davis, CA 95616, USA.
Ryan MaconCalifornia National Primate Research Center, University of California, Davis, CA 95616, USA.
J Russell HuieDepartment of Neurosurgery, University of California, San Francisco, CA 94143, USA.
Adam R FergusonDepartment of Neurosurgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-7102-1608
Mark H TuszynskiDepartment of Neurosciences, University of California-San Diego, La Jolla, CA 92093, USA.
Michael S BeattieDepartment of Neurosurgery, University of California, San Francisco, CA 94143, USA.
Jacqueline C BresnahanDepartment of Neurosurgery, University of California, San Francisco, CA 94143, USA.
Carolyn J SparreyMechatronic Systems Engineering, Simon Fraser University, Surrey, BC V3TOA3, Canada.ORCID 0000-0002-5524-4577

Funding

Plasticity and Regeneration in the Primate Spinal CordR01NS042291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRESNAHAN, JACQUELINE C, CAPITANIO, JOHN P · 2001 to 2015
$13.0M
The Primate Corticospinal Connectome and Transcriptome - SupplementR01NS104442 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUSZYNSKI, MARK H. · 2017 to 2025
$5.7M
Embryonic stem cell therapy after cervical contusion SCI in NHPsR01NS105478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2017 to 2021
$2.9M
NINDS NIH HHS R01 NS042291NINDS NIH HHS R01 NS104442NINDS NIH HHS R01 NS105478RRD VA I01 RX002245
6 · The paper itself

Abstract

backgroundA spinal cord contusion injury is among the most clinically relevant models for studying pathophysiology and for developing potential therapeutic interventions for spinal cord injuries (SCI).

methodsIn this study, we implemented an intra-operative ultrasound (IOU) approach to precisely locate and examine the lesion site at 5 and 10 min post-injury after a cervical hemi-contusion injury in a non-human primate (NHP) model. We assessed acute lesion progression from 5 to 10 min and then compared that to the lesion extent as measured by MRI 3 weeks later.

resultsWe observed a small increase in the rostrocaudal and mediolateral lesion area (mm

conclusionsBy enabling high-resolution ultrasound visualization of the hemicontusion lesion in vivo, this approach can provide critical insights into the early progression of SCI. It can help with further refining this preclinical SCI model and provide significant predictive value for the animals' recovery post-injury.

Indexed as

contusionintraoperativenon-human primatespinal cord injuryultrasound

Identifiers

PMID41008365
PMCPMC12468102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.