Evidence map›Paper›PMID 41008336›Full record

ArticleBrain sciences2025

Electroacupuncture Attenuates Fibromyalgia Pain Through Increased PD-1 Expression in Female Mice.

I-Han Hsiao, Wei-Hung Chen, Ming-Chia Lin, Hsin-Cheng Hsu, Hsien-Yin Liao, Yi-Wen Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

I-Han HsiaoSchool of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan.
Wei-Hung ChenDepartment of Anesthesiology, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan.
Ming-Chia LinDepartment of Nuclear Medicine, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan.
Hsin-Cheng HsuDepartment of Traditional Chinese Medicine, China Medical University Hsinchu Hospital, Hsinchu 302233, Taiwan.ORCID 0000-0002-9150-0339
Hsien-Yin LiaoSchool of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404328, Taiwan.
Yi-Wen LinGraduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 404328, Taiwan.ORCID 0000-0001-7204-8837

Funding

Chinese Medicine Research Center Chinese Medicine Research CenterCMUHCH-DMR-114-027 CMUHCH-DMR-114-027EDAHP114025 EDAHP114025NSTC 114-2314-B-039-031 NSTC 114-2314-B-039-031
6 · The paper itself

Abstract

BACKGROUND/

objectivesFibromyalgia causes chronic long-term pain, with symptoms lasting for months to years. Given the lack of evidence-based methods for diagnosing and assessing fibromyalgia, it ranks among the most difficult chronic pain conditions to treat. Programmed cell death ligand 1 (PD-L1) can inhibit acute and chronic pain transmission by inhibiting neuronal ion channels.

methodsHere, we aimed to explore the analgesic efficacy and mechanism of PD-L1/PD1 in an intermittent cold stress-induced fibromyalgia pain mouse model.

resultsVon Frey and Hargreaves tests were performed, showing that the mouse model exhibited mechanical (day 4: 2.08 ± 0.13 g,

conclusionsOur results show that EA can treat fibromyalgia pain in mice through effects on the PD-L1/PD1 pathway, indicating its potential as a therapeutic target in fibromyalgia.

Indexed as

acupunctureastrocytedorsal root gangliamicrogliaPD-L1TLR4

Identifiers

PMID41008336
PMCPMC12467811

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.