ArticleBrain sciences2025
The Involvement of Thalamic Nuclei in Schizophrenia Patients with and Without Auditory Verbal Hallucinations: A Brain Morphometry Study.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Thalamic nuclei volumes across psychiatric and neurological disorders: a multi-site magnetic resonance imaging study.Translational psychiatry · 2026Article
- NeuroMark-DyFICA: NeuroMark dynamic frequency-informed ICA with high-frequency spatial filtering for windowed fMRI analysis.Network neuroscience (Cambridge, Mass.) · 2026Article
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Abstract
backgroundThe thalamus, together with its associated nuclei and thalamocortical pathways, is crucial in understanding the neurobiological mechanisms underlying auditory verbal hallucinations (AVHs) in schizophrenia (SCZ). PURPOSE: The study investigates the role of thalamic nuclei in schizophrenia patients experiencing auditory verbal hallucinations (AVHs).
methodsA total of 21 healthy controls (HC), 22 schizophrenia patients without auditory verbal hallucinations (SCZ_AVH-), and 22 schizophrenia patients with auditory verbal hallucinations (SCZ_AVH+), aged between 19 and 65 years, were recruited. They underwent MRI scans, and participants in the SCZ_AVH+ group completed the assessment of the severity of different dimensions of auditory hallucinations and delusions using the psychotic symptom rating scale (PSYRATS). High-resolution T1-weighted imaging was utilized to analyze the volumes of the thalamic nuclei.
resultsThe volumetric analysis of the thalamic nuclei indicated a significant reduction (t = 2.64,
conclusionThe volumetric changes are observed in both SCZ_AVH- and SCZ_AVH+ groups, mainly in the thalamic nuclei. Structural deficits in the MGN may distinguish schizophrenia patients with AVHs from those without.
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