Evidence map›Paper›PMID 41007841›Full record

ArticleBiomedicines2025

The Prevalence of Diamine Oxidase Polymorphisms and Their Association with Histamine Intolerance Symptomatology in the Mexican Population.

Pamela Aguilar-Rodea, Viviana Mejía-Ramírez, Raúl Hernández-Munguía, Saúl Ramírez-Vargas, Diana Tovar-Vivar, Jaquelin Leyva-Hernández, Juan Carlos Nacar-Gutiérrez, Miriam Morales-Martínez, Aracely Palafox-Zaldivar

Abstract read
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In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pamela Aguilar-RodeaLaboratorios Columbia S.A. de C.V., Panzacola 62, Villa Coyoacán, Coyoacán, Mexico City 04000, Mexico.ORCID 0000-0002-1522-2138
Viviana Mejía-RamírezLaboratorios Columbia S.A. de C.V., Panzacola 62, Villa Coyoacán, Coyoacán, Mexico City 04000, Mexico.
Raúl Hernández-MunguíaLaboratorios Columbia S.A. de C.V., Panzacola 62, Villa Coyoacán, Coyoacán, Mexico City 04000, Mexico.
Saúl Ramírez-VargasLaboratorios Columbia S.A. de C.V., Panzacola 62, Villa Coyoacán, Coyoacán, Mexico City 04000, Mexico.
Diana Tovar-VivarLaboratorios Columbia S.A. de C.V., Panzacola 62, Villa Coyoacán, Coyoacán, Mexico City 04000, Mexico.
Jaquelin Leyva-HernándezLaboratorios Columbia S.A. de C.V., Panzacola 62, Villa Coyoacán, Coyoacán, Mexico City 04000, Mexico.
Juan Carlos Nacar-GutiérrezLaboratorios Columbia S.A. de C.V., Panzacola 62, Villa Coyoacán, Coyoacán, Mexico City 04000, Mexico.
Miriam Morales-MartínezLaboratorios Columbia S.A. de C.V., Panzacola 62, Villa Coyoacán, Coyoacán, Mexico City 04000, Mexico.
Aracely Palafox-ZaldivarLaboratorios Columbia S.A. de C.V., Panzacola 62, Villa Coyoacán, Coyoacán, Mexico City 04000, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exogenous histamine obtained from the intake of histamine-rich food is mainly metabolized by the diamine oxidase enzyme (DAO). Histamine intolerance (HIT) is an alteration mainly caused by DAO deficiency, which is commonly associated with gastrointestinal, respiratory, cardiovascular, central nervous system, muscular, skeletal, and skin symptoms. Despite four single-nucleotide polymorphisms (SNPs) being mainly associated with DAO deficiency, the probability of inheriting these variants and their relationship with HIT in the Mexican population remain unknown.

Indexed as

DAO deficiencydiamine oxidasehistamine intolerancepolymorphismsSNP inheritance

Identifiers

PMID41007841
PMCPMC12467063

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.