ArticleInternational journal of environmental research and public health2025
Predictors of Major Amputation and Mortality in Infected Diabetic Foot Ulcers: A Retrospective Nationwide Inpatient Sample Study.
Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Long-Term Mortality in Diabetic Foot Disease is Higher Than That of Overall Cancer: Results From Three International Cohorts.Diabetes/metabolism research and reviews · 2026Article
- Preoperative BUN-to-Albumin Ratio Is Independently Associated with Major Reamputation After Distal Amputation in Diabetic Foot: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Decapping scavenger enzyme as a promising biomarker in diabetic foot ulcers: A need for cautious interpretation.World journal of diabetes · 2026Article
- Hospital burden, amputation risk, and mortality trends in diabetic foot patients: a retrospective public health analysis.Frontiers in public health · 2026Article
- Long-Term Effect of a Structured Educational Program on Diabetic Foot on Major Adverse Limb and Cardiovascular Events in People with Type 1 Diabetes.Journal of clinical medicine · 2025Article
- Sequential application of vacuum sealing drainage and antibiotic-loaded bone cement for the successful treatment of a diabetic ischemic foot ulcer: a case report.Frontiers in endocrinology · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundDiabetic foot ulcers (DFUs) affect approximately 15% of diabetic patients and are the leading cause of non-traumatic lower extremity amputations worldwide. This study examines trends in DFU management, predictors of major amputation and in-hospital mortality, and the impact of comorbidities on outcomes.
methodsUsing the Nationwide Inpatient Sample (NIS) database (2016-2019), we analyzed non-elective admissions of DFU patients categorized into four treatment groups: no surgery, debridement, minor amputation, and major amputation (below-knee or above-knee). Statistical analyses identified factors associated with major amputation and mortality.
resultsA significant increase in minor amputations and debridement was observed between 2016 and 2019, while the number of major amputations declined (
conclusionsThese findings underscore the impact of comorbidities on DFU outcomes and emphasize the need for early intervention to reduce severe complications. Future research should focus on optimizing management strategies for high-risk patients to improve clinical and surgical outcomes.
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