Evidence map›Paper›PMID 41007449›Full record

ArticleBiology2025

Therapeutic Effects of Stem Cells from Human Exfoliated Deciduous Teeth and Their Conditioned Medium in Cisplatin-Induced Acute Kidney Injury: An In Vivo Study.

Ardeshir Talebi, Sahar Talebi, Sara Nikpoor, Nosrat Nourbakhsh, Hossein Talebi, Sareh Soroushzadeh, Miguel Gómez-Polo, Seyed Ali Mosaddad

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Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ardeshir TalebiDepartment of Pathology, Medical School, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Sahar TalebiDental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Sara NikpoorDepartment of Pathology, Medical School, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Nosrat NourbakhshDepartment of Pediatric Dentistry, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Hossein TalebiDepartment of Cellular and Molecular Biology, Falavarjan Islamic Azad University, Isfahan 84517-31167, Iran.
Sareh SoroushzadehIran Academic Center for Education, Culture and Research, Isfahan Branch, Isfahan 39998-81551, Iran.
Miguel Gómez-PoloDepartment of Conservative Dentistry and Prosthodontics, School of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0001-8614-8484
Seyed Ali MosaddadDepartment of Conservative Dentistry and Prosthodontics, School of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is a severe condition with high morbidity and mortality. Mesenchymal stem cells (MSCs) and their conditioned medium (MSCs-CM), containing extracellular vesicles (EVs), have shown therapeutic potential. This study evaluates the effects of stem cells from human exfoliated deciduous teeth (SHED) and their conditioned medium (SHED-CM) on cisplatin-induced AKI in an in vivo model.

methodsMale Wistar rats (n = 21) were randomly divided into three groups: a control group (cisplatin-induced AKI without intervention), a SHED group (receiving intraperitoneal SHED injections), and a SHED-CM group (receiving intraperitoneal SHED-CM injections). Kidney weight, urine parameters, histopathology, and injury scores were assessed.

resultsSHED-CM treatment significantly improved renal function, with reduced kidney injury scores (1.42 ± 0.18 vs. 2.57 ± 0.23 in the control,

conclusionsSHED-CM demonstrated superior therapeutic efficacy over SHED injection in mitigating cisplatin-induced AKI, likely due to extracellular vesicle-mediated paracrine effects. These findings support SHED-CM as a promising, non-invasive alternative for MSC-EV-based AKI therapy.

Indexed as

acute kidney injurycisplatinconditioned culture mediaextracellular vesiclesmesenchymal stem cells

Identifiers

PMID41007449
PMCPMC12467823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.