Evidence map›Paper›PMID 41007349›Full record

ArticleBiology2025

Acute Restraint Stress Impairs Aversive Memory Retention but Not Memory Formation.

Aline Lima Dierschnabel, Diana Aline Nôga, Luiz Eduardo Mateus Brandão, Catherine Caldas de Mesquita, Diego de Aquino Câmara, Ywlliane da Silva Rodrigues Meurer, Felipe Porto Fiuza, Rovena Clara Galvão Januário Engelberth, Regina Helena da Silva, Jeferson Souza Cavalcante and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aline Lima DierschnabelLaboratory of Neurochemical Studies, Physiology and Behaviour Department, Post-Graduation Program in Psychobiology, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Brazil.ORCID 0000-0001-5175-2139
Diana Aline NôgaLaboratory of Neurochemical Studies, Physiology and Behaviour Department, Post-Graduation Program in Psychobiology, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Brazil.
Luiz Eduardo Mateus BrandãoLaboratory of Neurochemical Studies, Physiology and Behaviour Department, Post-Graduation Program in Psychobiology, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Brazil.ORCID 0000-0002-8672-7870
Catherine Caldas de MesquitaSantos Dumont Institute, Edmond and Lily Safra International Institute of Neuroscience, Macaíba 59280-000, Brazil.
Diego de Aquino CâmaraSantos Dumont Institute, Edmond and Lily Safra International Institute of Neuroscience, Macaíba 59280-000, Brazil.ORCID 0000-0001-9160-5088
Ywlliane da Silva Rodrigues MeurerLaboratory of Neurochemical Studies, Physiology and Behaviour Department, Post-Graduation Program in Psychobiology, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Brazil.ORCID 0000-0003-0141-0880
Felipe Porto FiuzaSantos Dumont Institute, Edmond and Lily Safra International Institute of Neuroscience, Macaíba 59280-000, Brazil.ORCID 0000-0002-2146-9989
Rovena Clara Galvão Januário EngelberthLaboratory of Neurochemical Studies, Physiology and Behaviour Department, Post-Graduation Program in Psychobiology, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Brazil.
Regina Helena da SilvaBehavioural Neuroscience Laboratory, Department of Pharmacology, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo 04021-001, Brazil.ORCID 0000-0001-9017-3922
Jeferson Souza CavalcanteLaboratory of Neurochemical Studies, Physiology and Behaviour Department, Post-Graduation Program in Psychobiology, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Brazil.
Ramón Hypolito LimaSantos Dumont Institute, Edmond and Lily Safra International Institute of Neuroscience, Macaíba 59280-000, Brazil.ORCID 0000-0002-5471-9147

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance code 001Ministry of Education CONTRATO Nº 1/2021National Council for Scientific and Technological Development Universal grant 446663/2014-0
6 · The paper itself

Abstract

Stress can alter neurochemical signalling, affecting memory processing, but its underlying neurobiological mechanism remains unclear. Here, we investigate the effect of acute restraint stress (ARS) on long-term retention of aversive memory in rats. We exposed the animals to either handling or an ARS protocol and tested the rats in the plus-maze discriminative avoidance task (PMDAT). Also, we performed immunohistochemistry assays to unveil the effect of stress on neuronal activity. We found that ARS immediately after training does not impair memory formation but hinders retention. Training triggers a peak of C-fos 1 h later and a delayed 18 h increase in Zif268 in dorsal CA1. The same does not occur when ARS is experienced immediately after training. We demonstrated that the crucial role of Zif268 and C-fos signalling in maintaining PMDAT LTM. ARS is more relevant for memory retention than for the formation of discriminative aversive memory.

Indexed as

aversive memory retentionC-foshippocampusplus-maze discriminative avoidance taskstressZif268

Identifiers

PMID41007349
PMCPMC12467883

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.