Evidence map›Paper›PMID 41007316›Full record

ArticleBiology2025

High Salt Intake Affects Visceral Adipose Tissue Homeostasis: Beneficial Effects of GLP-1 Agonists.

Vanessa Touceda, Leonardo Cacciagiú, Ignacio Barbani Moglie, Morena Wiszniewski, Valeria Sanchez, Romina C De Lucca, Agustina Vidal, Paola Finocchietto, Silvia Friedman, Germán E González and 1 more

Abstract read
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vanessa ToucedaLaboratorio de Patología Cardiovascular Experimental e Hipertensión Arterial, Instituto de Investigaciones Biomédicas (UCA-CONICET), Facultad de Medicina, Pontificia Universidad Católica Argentina, Buenos Aires C1107AFF, Argentina.ORCID 0000-0003-2230-1552
Leonardo CacciagiúUnidad de Investigación en Bioquímica Traslacional y Metabolismo (UBiTyM), Cátedra de Bioquímica General y Bucal, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires C1107AFF, Argentina.
Ignacio Barbani MoglieLaboratorio de Patología Cardiovascular Experimental e Hipertensión Arterial, Instituto de Investigaciones Biomédicas (UCA-CONICET), Facultad de Medicina, Pontificia Universidad Católica Argentina, Buenos Aires C1107AFF, Argentina.ORCID 0009-0000-5515-9850
Morena WiszniewskiUnidad de Investigación en Bioquímica Traslacional y Metabolismo (UBiTyM), Cátedra de Bioquímica General y Bucal, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires C1107AFF, Argentina.ORCID 0000-0003-2191-981X
Valeria SanchezInstituto de Investigaciones Biomédicas (UCA-CONICET), Facultad de Medicina, Pontificia Universidad Católica Argentina, Buenos Aires C1107AFF, Argentina.
Romina C De LuccaCátedra de Histología y Embriología, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires C1107AFF, Argentina.ORCID 0000-0002-4785-6020
Agustina VidalInstituto de Investigaciones Biomédicas (UCA-CONICET), Facultad de Medicina, Pontificia Universidad Católica Argentina, Buenos Aires C1107AFF, Argentina.
Paola FinocchiettoUnidad de Investigación en Bioquímica Traslacional y Metabolismo (UBiTyM), Cátedra de Bioquímica General y Bucal, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires C1107AFF, Argentina.
Silvia FriedmanUnidad de Investigación en Bioquímica Traslacional y Metabolismo (UBiTyM), Cátedra de Bioquímica General y Bucal, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires C1107AFF, Argentina.
Germán E GonzálezLaboratorio de Patología Cardiovascular Experimental e Hipertensión Arterial, Instituto de Investigaciones Biomédicas (UCA-CONICET), Facultad de Medicina, Pontificia Universidad Católica Argentina, Buenos Aires C1107AFF, Argentina.ORCID 0000-0002-4433-9837
Verónica MiksztowiczUnidad de Investigación en Bioquímica Traslacional y Metabolismo (UBiTyM), Cátedra de Bioquímica General y Bucal, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires C1107AFF, Argentina.

Funding

National Agency of Promotion of Science and Technology PICT 2019-02987National Agency of Promotion of Science and Technology PICT 2021-GRF-TI-0042University of Buenos Aires UBACYT 20020220200089BA
6 · The paper itself

Abstract

High salt (NaCl) intake has been associated with visceral adipose tissue (VAT) dysfunction independently of its impact on blood pressure. Liraglutide (LGT), a GLP-1 agonist, could be a potential therapeutic option. We investigated the impact of a chronic high-salt diet (HSD) on VAT homeostasis and evaluated the potential protective effects of LGT, a GLP-1 receptor agonist. Male C57BL/6 mice were fed a standard diet (Control, C) or 8% NaCl (HSD) for 15 weeks and subsequently treated with LGT or vehicle for 5 weeks. In VAT, histological characteristics, collagen deposition, vascular density, mitochondrial dynamics, oxidative stress, and adipokine expression were evaluated. The HSD significantly decreased body weight, VAT mass, and adipocyte size (

Indexed as

adipose tissuefibrosishigh salt intakeliraglutidevascular density

Identifiers

PMID41007316
PMCPMC12467069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.