Evidence map›Paper›PMID 41007069›Full record

ArticleChildren (Basel, Switzerland)2025

High-Intensity Physical Activity During Late Adolescence Predicts Young Adult CT-Based Finite Element Bone Strength in Emerging Adulthood: Iowa Bone Development Study.

Soyang Kwon, Kathleen F Janz, Indranil Guha, Alex V Rowlands, Oscar Rysavy, Punam K Saha, Chandler Pendleton, Euisung D Shin, Steven M Levy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Soyang KwonBuehler Center for Health Policy and Economics, Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-9359-704X
Kathleen F JanzDepartment of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA.
Indranil GuhaDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, USA.
Alex V RowlandsDiabetes Research Centre, College of Life Sciences, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0002-1463-697X
Oscar RysavyDepartment of Biostatistics, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-1019-5724
Punam K SahaDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, USA.
Chandler PendletonDepartment of Biostatistics, University of Iowa, Iowa City, IA 52242, USA.
Euisung D ShinEmergency and Family Medicine Residency Program, Christina Care Health Systems, Newark, DE 19716, USA.
Steven M LevyDepartment of Preventive and Community Dentistry, University of Iowa, Iowa City, IA 52242, USA.

Funding

UNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8M
XANTHINE OXIDASE PRODUCTS IN MODULATION OF ENDOTHELIAL DYSFUNCTIONM01RR000059 · NCRR · UNIVERSITY OF IOWA · PI AHRENS, RICHARD C · 1985 to 2007
$22.3M
Fluoride & Other Factors in Childhood and Adolescent Bone DevelopmentR01DE012101 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1998 to 2013
$11.9M
LONGITUDINAL STUDY OF FLUORIDE EXPOSURES &FLUORIDER01DE009551 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1991 to 2008
$4.7M
The interactive effects of physical activity and sedentary behaviors during childhood on adiposity in early adulthoodR03HD100657 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI KWON, SOYANG · 2020 to 2021
$153k
National Institute of Child Health and Development R03HD100657NCRR NIH HHS M01 RR000059NCRR NIH HHS M01-RR00059NCRR NIH HHS UL1 RR024979NICHD NIH HHS R03 HD100657NIDCR NIH HHS R01 DE009551NIDCR NIH HHS R01 DE012101NIDCR NIH HHS R01-DE09551NIDCR NIH HHS R01-DE12101
6 · The paper itself

Abstract

objectiveThis study investigated associations between physical activity (PA) during late adolescence and emerging adulthood and bone strength in emerging adulthood by utilizing advanced finite element analysis of computed tomography (CT/FEA) technology beyond the traditional dual-energy X-ray absorptiometry (DXA) method.

methodsThis study included 266 participants (152 females) from the Iowa Bone Development Study. PA volume (average acceleration) and intensity (intensity gradient) metrics were calculated from ActiGraph accelerometer data collected at ages 17, 19, 21, and 23 years. Compressive modulus and compressive stiffness of the tibia were estimated at age 23 via CT/FEA of the tibia. Sex-specific linear regression models were used to evaluate associations between PA metrics and bone outcomes, adjusting for age, height, weight, musculoskeletal fitness, and calcium intake.

resultsIntensity gradient averaged over 17-23 years of age was positively associated with compressive stiffness at age 23 years in both females and males (

conclusionsUsing a state-of-the-art CT/FEA method, this study suggests that high-intensity PA during late adolescence and emerging adulthood improves bone strength.

Indexed as

adolescent bone healthcohort studycomputed tomography (CT)finite element analysis (FEA)musculoskeletal fitnessphysical activity intensityphysical activity volumeyoung adult bone integrity

Identifiers

PMID41007069
PMCPMC12468735

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.