Evidence map›Paper›PMID 41007054›Full record

ReviewChildren (Basel, Switzerland)2025

An Evolutionary Preamble Towards a Multilevel Framework to Understand Adolescent Mental Health: An International Delphi Study.

Federica Sancassiani, Vanessa Barrui, Fabrizio Bert, Sara Carucci, Fatma Charfi, Giulia Cossu, Arne Holte, Jutta Lindert, Simone Marchini, Alessandra Perra and 6 more

Abstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Federica SancassianiDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0002-7963-5281
Vanessa BarruiDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0003-0535-306X
Fabrizio BertDepartment of Public Health and Pediatrics Sciences, University of Turin, 10124 Turin, Italy.ORCID 0000-0002-4329-9028
Sara CarucciDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0001-5776-5555
Fatma CharfiResearch Laboratory LR22SP01, Department of Child Psychiatry, Mongi Slim Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis 1068, Tunisia.ORCID 0000-0002-5171-2767
Giulia CossuDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0002-1245-016X
Arne HolteDepartment of Psychology, University of Oslo, 0313 Oslo, Norway.ORCID 0000-0001-8156-2192
Jutta LindertDepartment of Social Work and Health, University of Emden/Leer, 26723 Emden, Germany.ORCID 0000-0001-5368-3886
Simone MarchiniDepartment of Child and Adolescent Psychiatry, Site Anderlecht, Hôpital Universitaire de Bruxelles, 1070 Brussels, Belgium.ORCID 0000-0002-0432-5705
Alessandra PerraDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0001-5791-1655
Samantha PinnaDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.ORCID 0009-0005-5152-3834
Antonio Egidio NardiLaboratory of Panic and Respiration-IPUB, Institute of Psychiatry of the Federal University of Rio de Janeiro, Rio de Janeiro 22290-140, Brazil.ORCID 0000-0002-2152-4669
Alessandra ScanoDepartment of Surgical Sciences, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0002-4385-8002
Cesar A Soutullo"Louis A. Faillace MD" Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth Houston), Houston, TX 77054, USA.ORCID 0000-0003-4348-0772
Massimo TusconiCenter of Liason Psychiatry and Psychosomatics, University Hospital of Cagliari, 09126 Cagliari, Italy.ORCID 0000-0002-9155-4740
Diego PrimaveraDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.ORCID 0009-0004-6335-003X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesAdolescence is a sensitive developmental window shaped by both vulnerabilities and adaptive potential. From an evolutionary standpoint, mental health difficulties in this period may represent functional responses to environmental stressors rather than mere dysfunctions. Despite increasing interest, integrative models capturing the dynamic interplay of risk and protective factors in adolescent mental health remain limited. This study presents a holistic, multi-level framework grounded in ecological and evolutionary theories to improve understanding and intervention strategies.

methodsA two-round Delphi method was used to develop and validate the framework. Twelve experts in adolescent mental health evaluated a preliminary draft derived from the literature. In Round 1, 12 items were rated across five criteria (YES/NO format), with feedback provided when consensus thresholds were not met. Revisions were made using consensus index scores. In Round 2, the revised draft was assessed across eight broader dimensions. A consensus threshold of 0.75 was used in both rounds.

resultsTwelve out of thirteen experts (92%) agreed to join the panel. Round 1 item scores ranged from 0.72 to 0.85, with an average consensus index of 0.78. In Round 2, ratings improved significantly, ranging from 0.82 to 1.0, with an average of 0.95. The Steering Committee incorporated expert feedback by refining the structure, deepening content, updating sources, and clarifying key components.

conclusionsThe final framework allows for the clustering of indicators across macro-, medium-, and micro-level domains. It offers a robust foundation for future research and the development of targeted, evolutionarily informed mental health interventions for adolescents.

Indexed as

adolescentDelphi techniqueepigenesisgeneticmental healthsocial determinants of health

Identifiers

PMID41007054
PMCPMC12468673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.