Evidence map›Paper›PMID 41007013›Full record

ArticleChildren (Basel, Switzerland)2025

Impact of a Cystic Fibrosis Specific Multivitamin Formulation on Fat-Soluble Vitamin Status and Treatment Satisfaction in Young Children.

Anne Munck, Raphael Enaud, Jeanne Languepin, Natascha Remus, Nathalie Wizla, Frederique Chedevergne, Stephanie Bui, Amelie Arrouy, Marie Mittaine, Megan Quinn and 2 more

Abstract read
In one paragraph

Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anne MunckHospital Necker Enfants Malades, CF Center, 75015 Paris, France.ORCID 0000-0003-2331-278X
Raphael EnaudHospital Pellegrin-Enfants, CF Center, CIC, 33000 Bordeaux, France.
Jeanne LanguepinCHU Dupuytren, CF Center, 87000 Limoges, France.ORCID 0000-0002-4646-018X
Natascha RemusIntercommunal Hospital, Center on Rare Respiratory Diseases, 94000 Creteil, France.ORCID 0000-0003-4849-9034
Nathalie WizlaUniversity Hospital Lille, Paediatric CF Center, 59037 Lille, France.
Frederique ChedevergneHopital Necker-Enfants Malades, CF Center, 75015 Paris, France.
Stephanie BuiHopital Pellegrin, Paediatric CF Center, 33000 Bordeaux, France.ORCID 0000-0003-3576-2518
Amelie ArrouyUniversity Hopital des Enfants, CIC, 31300 Toulouse, France.
Marie MittaineUniversity Hopital des Enfants, Paediatric CF Center, 31300 Toulouse, France.ORCID 0000-0003-2385-495X
Megan QuinnDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN 37614, USA.
Amy WahlquistDepartment of Biostatistics and Epidemiology, College of Public Health, Center for Rural Health and Research, East Tennessee State University, Johnson City, TN 37614, USA.
Isabelle Sermet-GaudelusHopital Necker-Enfants Malades, CF Center, Inserm U1151, Universite Paris Cite, 75015 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildren with cystic fibrosis (CwCF) are at increased risk of fat-soluble vitamin (FSV) deficiency due to fat malabsorption. In France, children were usually supplemented with multiple individual vitamin preparations but have recently converted to DEKAs Plus Liquid (DPL), an absorption-enhanced, CF-specific, multivitamin formulation that includes vitamins D

methodsYoung CwCF (n = 39, mean age 2.3 ± 1.1 years) were analyzed retrospectively. Serum FSV levels, prothrombin time, treatment satisfaction, and compliance were assessed at baseline (M0) and after 12 months (M12).

resultsPaired data analysis was performed on the 34 who completed 12 months. After 3 months, the initial daily dose was adjusted in nine cases. Median (interquartile range) serum levels of vitamin E (19.3 (17-27) vs. 26.3 (20-31) µmol/L,

conclusionsSwitching from individual vitamins to DPL reduced vitamin deficiencies and improved FSV levels and patient satisfaction.

Indexed as

cystic fibrosisDEKAs Plus Liquidexocrine pancreatic insufficiencyfat-soluble vitaminsnutritional statuspediatric nutritionvitamin absorptionvitamin deficiencyvitamin supplementation

Identifiers

PMID41007013
PMCPMC12468447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.