ArticleInternational journal of obesity (2005)2025
Cardiovascular risk factors associated with BMI and metabolic health phenotypes based on measures of coagulation factors.
Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A Machine Learning-Based Clinical Decision Support Tool for Intertrochanteric Hip Fracture Patients to Predict Postoperative Anemia Risk: A Retrospective Cohort Study.Bioengineering (Basel, Switzerland) · 2026Article
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9 authors.
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Abstract
introductionWhile the classification of metabolically healthy individuals with obesity remains uncertain, recent research links central obesity to thromboembolism and cardiovascular disease, potentially indicating a hypercoagulable state in some individuals with obesity. This study investigates coagulation and inflammation differences between obesity and normal-weight phenotypes.
methods225 adult women, participants were subjected to clinical examinations, and biochemical assessments. These assessments classified participants into four distinct phenotypes, namely MHNW (individuals with Metabolically Healthy Normal Weight), MUNW (individuals with Metabolically Unhealthy Normal Weight), MHO (individuals with Metabolically Healthy Obesity), and MUO (individuals with Metabolically Unhealthy Obesity), based on a combination of body mass index (BMI) and metabolic criteria. Subsequently, hemostatic proteins and interleukin levels were compared.
resultsAmong 225 female patients, the MHO group was younger, with higher measurements like visceral fat and BMI, while MUO had the highest values in homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides and low-density lipoprotein cholesterol (LDL-c). Coagulation proteins showed normal levels. However, MHNW had significantly lower FV, and groups without obesity (MHNW and MUNW) had lower FVIII and FIX. FXII in MHNW did not significantly differ. Inflammatory markers revealed IL-6 negatively correlated with PC and AT but positively with FVIII and FIX. IL-10 negatively correlated with FII, FV, FVII, FXI, and FXII, while TNF-α and IL-1 positively correlated with FVIII and FIX.
conclusionThis study challenges the MUNW metric, revealing metabolic marker elevations in women without obesity. Additionally, MHO individuals exhibited pro-coagulant protein increases compared to MUO, suggesting limited clinical utility in categorizing the broader population with obesity. Our exploratory findings highlight how the interplay between metabolic health and body size phenotypes could challenge conventional frameworks for assessing health risk.
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