Evidence map›Paper›PMID 41006770›Full record

ArticleCommunications biology2025

RhoA allosterically activates phospholipase Cε via its EF hands.

Vaani Ohri, Kadidia Samassekou, Kaushik Muralidharan, Elisabeth E Garland-Kuntz, Isaac J Fisher, William C Hogan, Bailey M Davis, Angeline M Lyon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Vaani OhriDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0003-3344-855X
Kadidia SamassekouJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-3449-2037
Kaushik MuralidharanAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-3457-5019
Elisabeth E Garland-KuntzJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Isaac J FisherJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
William C HoganDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Bailey M DavisDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Angeline M LyonDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA. lyonam@purdue.edu.ORCID http://orcid.org/0000-0001-7501-0148

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Structural Studies of PLCepsilon a regulator of cardiac contractility and hypertrophy.R01HL141076 · NHLBI · PURDUE UNIVERSITY · PI Angeline Marie Lyon · 2018 to 2026
$2.5M
NCI NIH HHS P30 CA023168NHLBI NIH HHS R01 HL141076U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL141076
6 · The paper itself

Abstract

Phospholipase Cε (PLCε) cleaves phosphatidylinositol lipids to increase intracellular Ca

Indexed as

EF Hand MotifsPhosphoinositide Phospholipase CrhoA GTP-Binding ProteinAllosteric RegulationAnimalsCell LineEnzyme ActivationHumansModels, MolecularProtein BindingProtein Structure, QuaternaryProtein Structure, TertiaryRatsPhosphoinositide Phospholipase Cphospholipase C epsilonrhoA GTP-Binding ProteinRHOA protein, human

Identifiers

PMID41006770
PMCPMC12475037

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.