ArticleCommunications biology2025
Systems-level exploitation of OxyR regulon unravels a potential antibacterial target in Pseudomonas aeruginosa.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Diversity, biofilm formation and antimicrobial susceptibility of aerobic heterotrophic bacteria isolated from cooling towers.World journal of microbiology & biotechnology · 2026Article
- Factors governing the response ofFrontiers in cellular and infection microbiology · 2026Review
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Authors and funding
12 authors.
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Abstract
Bacteria coordinate the response to oxidative stress through LysR-type transcriptional regulator (LTTR) OxyR. However, only fragmentary information on the regulation and function of OxyR has been gleaned in the opportunistic pathogen Pseudomonas aeruginosa. Here, we delineate the OxyR regulon using multi-omics analyses. OxyR is found to positively regulate several genes involved in quorum sensing (QS) and energy metabolism. OxyR is further involved in the negative regulation of amino acid transporters that was confirmed by metabolomics analysis. Finally, we uncover gltS, an OxyR regulon gene, could be used as a potential drug potentiation target. Altogether, our results confirm that, apart from its dominant role in defense against oxidative stress in P. aeruginosa, OxyR acts as a global regulator of QS, energy metabolism and amino acid homeostasis, but also serves as a model system to identify potential antibacterial target such as gltS.
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