ArticleNature plants2025
Nutrient-driven TOR signalling controls a chromatin-associated complex for orchestrating plant growth and stress tolerance.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- bZIP Transcription Factor PobZIP8 Positively Mediates Heat Stress Tolerance and Negatively Regulates the Growth and Development of Pleurotus ostreatus.Microbial biotechnology · 2026Article
- Functional characterisation of Target of Rapamycin (TOR) signalling in Physcomitrella.Plant cell reports · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The conserved target of rapamycin (TOR) kinase acts as a master regulator of growth by integrating nutrient and environmental signals in eukaryotes. However, how TOR influences chromatin remains poorly understood. Here we identified a multi-subunit complex in Arabidopsis thaliana, termed the chromatin-associated complex for growth (CACG). Our findings indicate that under nutrient-rich conditions, active TOR kinase enhances CACG mRNA translation, which is facilitated by pyrimidine-rich motifs in their 5' untranslated regions. CACG components co-occupy stress-responsive genes marked by histone acetylation, repressing their transcription to promote growth. Conversely, under nutrient-deficient conditions, inactive TOR reduces CACG mRNA translation, relieving transcriptional repression of stress-responsive genes and leading to increased stress tolerance but impaired growth. These results indicate that the CACG complex acts as a critical nutrient-responsive transcriptional regulator that is required for coordinating plant growth and stress tolerance in a TOR-dependent manner. The molecular mechanism revealed here could aid in developing high-yield crops capable of thriving in adverse environments.
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Registered trials
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