ArticleScientific reports2025
Noninvasive evaluation of renal oxygenation by blood oxygenation level-dependent magnetic resonance imaging in patients with primary aldosteronism.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Rethinking flow: the paradox of renoprotection without increased renal blood flow in cardiopulmonary bypass.Journal of thoracic disease · 2026Article
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13 authors.
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Abstract
This study investigated renal oxygenation status in primary aldosteronism (PA) patients using blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI), with comparative analysis against healthy controls and correlation assessments with biochemical markers of renal function. A total of 48 patients and 27 healthy controls were enrolled. All participants underwent renal BOLD-MRI with a 3 T MRI scanner. The R2* values were measured in the renal cortex and medulla of the bilateral kidneys using the region of interest method. Paired-sample t tests and independent-samples t tests were used. Pearson correlation analysis examined the relationship between R2* values and clinical indicators, and ROC curve analysis evaluated the performance of R2* values in distinguishing PA patients from healthy controls. The cortical R2* values were significantly lower than the medullary R2* values for all participants. For PA patients, left kidney cortical and medullary R2* values were significantly higher than those of the right kidney. Left kidney cortical R2* values in PA patients were significantly higher than in healthy controls. Medullary R2* values positively correlated with blood urea nitrogen (r = 0.408, p = 0.005). The optimal threshold for left cortical R2* in discriminating PA patients from healthy controls was 18.955 Hz, yielding a sensitivity of 75.5% and a specificity of 63.0%, with an AUC of 0.717 (95% CI, 0.593-0.841). BOLD-MRI can detect renal hypoxia in patients with PA, suggesting its potential as a noninvasive tool for renal assessment. Specifically, the cortical R2* value in the left kidney demonstrated a moderate ability (AUC = 0.717) to distinguish PA patients from healthy controls.
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