Evidence map›Paper›PMID 41006611›Full record

ArticleScientific reports2025

Proof-of-concept for an alternative prion detection method utilizing nanoparticle-enhanced, aptamer-template loop-mediated isothermal amplification.

Joseph H Ramos, Yuri Matsuoka, Alaa H Sewid, J Hunter Rice, Durina Z Dalrymple, Shigetoshi Eda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph H RamosSchool of Natural Resources, The University of Tennessee, Knoxville, TN, USA.
Yuri MatsuokaSchool of Natural Resources, The University of Tennessee, Knoxville, TN, USA.
Alaa H SewidSchool of Natural Resources, The University of Tennessee, Knoxville, TN, USA.
J Hunter RiceSchool of Natural Resources, The University of Tennessee, Knoxville, TN, USA.
Durina Z DalrympleDepartment of Microbiology, The University of Tennessee, Knoxville, TN, USA.
Shigetoshi EdaSchool of Natural Resources, The University of Tennessee, Knoxville, TN, USA. seda@utk.edu.

Funding

Chronic Wasting Disease Alliance A24-1017U.S. Department of Agriculture Agricultural Research Service A22-0225U.S. Department of Agriculture Animal and Plant Health Inspection Service AP23WSNWRC00C073
6 · The paper itself

Abstract

Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are fatal neurodegenerative disorders found across various host species. Chronic wasting disease (CWD) of cervids is among the TSEs afflicting wildlife populations. Widely distributed in North America, CWD has a devastating impact on cervid populations, and is an economic burden to government agencies and the cervid industry. Because prion diseases have no treatment, surveillance is critical to managing CWD. Current diagnostic approaches infer TSE disease status via measurement of pathogenic prion (PrP

Indexed as

Aptamers, NucleotideMolecular Diagnostic TechniquesNanoparticlesNucleic Acid Amplification TechniquesPrion DiseasesPrionsWasting Disease, ChronicAnimalsDeerProof of Concept StudyAptamers, NucleotidePrions

Identifiers

PMID41006611
PMCPMC12475493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.