Probable respiratory sarcopenia and 9-year mortality in community-dwelling older adults: the first longitudinal evidence from the CHARLS.

Yan Zhu, Qifeng Chen, Mingang Huang, Kangkang Chen

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Yan ZhuEmergency Internal Medicine, Shaoxing Seventh People's Hospital (Affiliated Mental Health Center, Medical College of Shaoxing University), Shaoxing, China.

Qifeng ChenDepartment of Non-communicable Diseases Control and Prevention, Shaoxing Center for Disease Control and Prevention, 276 Century Street, Shaoxing, 312000, Zhejiang Province, China.

Mingang HuangDepartment of Non-communicable Diseases Control and Prevention, Shaoxing Center for Disease Control and Prevention, 276 Century Street, Shaoxing, 312000, Zhejiang Province, China.

Kangkang ChenDepartment of Non-communicable Diseases Control and Prevention, Shaoxing Center for Disease Control and Prevention, 276 Century Street, Shaoxing, 312000, Zhejiang Province, China. sxcdc_ck@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

a position paper by the Japanese Working Group for Respiratory Sarcopenia (JWGRS). However, the clinical values of probable RS remain unclear. Therefore, we conducted a longitudinal study to determine its impacts on short- and long-term all-cause mortality. Our data were extracted from the China Health and Retirement Longitudinal Study. A total of 5,006 participants were selected as a cohort in 2011, and followed up until 2020. According to the JWGRS, probable RS was defined as a coexistence of low respiratory muscle strength and low appendicular skeletal muscles (ASM) mass. Hazard ratios (HRs) for all-cause mortality and cause-specific mortality were calculated through Cox regression analyses. After an average of 9 years of follow up, 1,176 of the 5,006 participants (23.49%) died. Cox proportional hazard regression showed that low ASM mass (HR = 1.24, 95% CI = 1.09-1.41, P < 0.001), low respiratory muscle strength (HR = 1.31, 95% CI = 1.11-1.54, P = 0.001), and probable RS (HR = 1.31, 95% CI = 1.15-1.48, P < 0.001) were associated with increased all-cause mortality. However, when the follow-up period was shortened to 2 years, the association between probable RS and all-cause mortality became non-significant (P = 0.246), although it remained significant for respiratory-related mortality (HR = 3.16, 95% CI = 1.39-7.18, P = 0.006). Diagnosing probable RS and leading to intervention could significantly prevent and reduce the burden of long-term all-cause mortality.

Indexed as

Respiratory MusclesSarcopeniaAgedAged, 80 and overChinaFemaleHumansIndependent LivingLongitudinal StudiesMaleMiddle AgedMuscle, SkeletalMuscle StrengthProportional Hazards ModelsRisk FactorsCHARLSLongitudinal investigationsMortalityOlder adultsRespiratory sarcopenia

Identifiers

PMID41006472

DOI10.1038/s41598-025-18511-y

PMCPMC12474932

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.