Evidence map›Paper›PMID 41006456›Full record

Observational studyScientific reports2025

Quantification of hounsfield unit difference in heterogeneous hematoma predicts poor functional outcomes in acute intracerebral hemorrhage.

Qian Wu, Lei Huang, Na Chen, Siying Ren, Fei Ye, Xu Zhao, Guofeng Wu, Likun Wang

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05548530 (Analysis of Related Factors of Hematoma Morphology in Patients With Cerebral Hemorrhage and Prognosis Analysis of Different Regimens for Cerebral Hemorrhage), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05548530 recruitingnot on this map

Analysis of Related Factors of Hematoma Morphology in Patients With Cerebral Hemorrhage and Prognosis Analysis of Different Regimens for Cerebral Hemorrhage

TypeobservationalSponsorThe Affiliated Hospital Of Guizhou Medical UniversityRan2014 to 2028Enrolled1,000ConditionsBrain HemorrhageArmsStereotactic intracranial hematoma puncture, decompressive craniectomy, Neuroendoscopic
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qian Wu *Emergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou Province, People's Republic of China.
Lei Huang *Laboratory of Emergency Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Na ChenLaboratory of Emergency Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Siying RenEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou Province, People's Republic of China.
Fei YeEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou Province, People's Republic of China.
Xu ZhaoEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou Province, People's Republic of China.
Guofeng WuEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou Province, People's Republic of China.
Likun WangEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou Province, People's Republic of China. 769070308@qq.com.

Funding

Key laboratory of Guizhou Medical University [2024] fy007Natural Science Foundation of China 82260244The Leading Discipline Program of the Affiliated Hospital of Guizhou Medical University gyfyxkyc-2023-05
6 · The paper itself

Abstract

Heterogeneous hematoma exhibiting a blend sign undergo dynamic changes associated with neurological injury. This study quantified hyperdense and hypodense regions of blend sign on serial non-contrast computed tomography (NCCT) using ITK-SNAP, calculated the mean hounsfield unit (HU) difference (dHU), and evaluated its prognostic value in 261 patients with intracerebral hemorrhage (ICH). All patients underwent baseline CT within 6 h of symptom onset and follow-up CT within 24 h. Logistic regression and ROC analysis showed that a higher dHU was independently associated with secondary neurological deterioration, 30-day mortality, and poor 3-month functional outcomes. A dHU > 3.25 predicted poor prognosis with good specificity (AUC 0.707, P < 0.001). These findings suggest that the dHU of heterogeneous hematoma based on serial CT scans is independently associated with poor outcomes after acute ICH.Trial registration: https://ClinicalTrials.gov , NCT05548530.

Indexed as

Cerebral HemorrhageHematomaTomography, X-Ray ComputedAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisROC CurveBlend signComputed tomographyDifference of mean hounsfield units (dHU)Intracerebral hemorrhagePoor outcomes

Identifiers

PMID41006456
PMCPMC12475111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.