ArticleScientific reports2025
Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Antioxidant and metabolic responses of Linum album cell culture to polyethylene glycol-induced drought stress.BMC plant biology · 2026Article
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6 authors.
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Abstract
Melatonin is a regulatory molecule that increases secondary metabolite biosynthesis in plants. Berberis vulgaris L. is a well-known medicinal plant, valued for its alkaloids and phenolic compounds. This study aimed to determine whether and how melatonin affects biosynthesis of alkaloids (particularly berberine) and phenolics in B. vulgaris. For this, cell cultures were treated with 0, 25, 50, and 100 µM melatonin, and the contents of berberine, phenolics, and amino acids, activity of phenylalanine ammonia-lyase (PAL) and tyrosine ammonia-lyase (TAL), and oxidative status were assessed. Melatonin altered total alkaloid and berberine contents, with the highest level observed at 50 µM (1.63 mg g
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