Evidence map›Paper›PMID 41006433›Full record

ArticleScientific reports2025

Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models.

Allyssa Bradley, Soyoung Park, Soyeon Park, Kyle Kim, Angela Galdamez, Hyejung Min, Monica Sophia Diaz-Aguilar, M Elizabeth Hartnett, Eun-Jin Lee, Jonathan H Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Allyssa BradleyDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Soyoung ParkDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Soyeon ParkDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Kyle KimDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Angela GaldamezDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Hyejung MinDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Monica Sophia Diaz-AguilarDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
M Elizabeth HartnettDepartment of Ophthalmology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Eun-Jin LeeDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Jonathan H LinDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA. Jonathan.H.Lin@stanford.edu.

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Mechanisms of Angiogenesis of Retinopathy of PrematurityR01EY015130 · NEI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mary Elizabeth Ruth Hartnett · 2005 to 2026
$7.6M
BLRD VA I01 BX002284California Institute for Regenerative Medicine DISC2-10973NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY015130NIH HHS P30EY026877U.S. Department of Veterans Affairs Merit I01BX002284
6 · The paper itself

Abstract

Pathological retinal neovascularization is a cause of vision loss in diseases including retinopathy of prematurity (ROP), wet age-related macular degeneration (AMD), and diabetic retinopathy. The Unfolded Protein Response (UPR) is an intracellular signal transduction mechanism that is activated by ER stress and upregulates many proteins, including angiogenesis factors like VEGF and HIF-1α. This suggests that UPR genes and pathways may drive retinal angiogenesis. Here, we tested the role of the UPR regulator Activating Transcription Factor 6 (ATF6) in pathological and developmental retinal angiogenesis. We induced pathological retinal neovascularization in Atf6

Indexed as

Activating Transcription Factor 6Retinal NeovascularizationAnimalsCell ProliferationDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutRetinaRetinopathy of PrematuritySignal TransductionUnfolded Protein ResponseActivating Transcription Factor 6Atf6 protein, mouse

Identifiers

PMID41006433
PMCPMC12475287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.