Evidence map›Paper›PMID 41006425›Full record

ArticleScientific reports2025

Time-course observation of tear film dynamics during VR headset use.

Yoshiro Okazaki, Norihiko Yokoi

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yoshiro OkazakiFaculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa-shi, Saitama, 359-1192, Japan. y.okazaki@waseda.jp.
Norihiko YokoiDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Funding

Japan Society for the Promotion of Science 22K20513
6 · The paper itself

Abstract

Dry eye disease is characterized by tear film instability, often linked to a reduced blink rate during prolonged visual display use. Although blink suppression during virtual reality (VR) headset use has been reported, its effect on tear film stability remains unclear. Accordingly, we developed a system using an ultra-compact camera for the time-course, noninvasive observation of tear film dynamics. Fourteen healthy participants played a 30-min VR game while tear film kinetics were analyzed. As gameplay progressed, a significant increase in the interference grade of the tear film lipid layer was observed (p < 0.05), along with elevated corneal and upper eyelid surface temperatures (p < 0.05). The increased interference grade suggests thickening of the lipid layer, possibly attributable to a periocular temperature elevation which may result in facilitation of the incorporation of polar lipids into the nonpolar lipid layer. These findings suggest that VR headset use may increase lipid layer thickness, potentially improving tear film stability under these conditions.

Indexed as

TearsVirtual RealityAdultBlinkingDry Eye SyndromesFemaleHumansMaleYoung AdultDry eye diseaseTear film lipid layerTear film stabilityVirtual reality headset

Identifiers

PMID41006425
PMCPMC12475124

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.