ArticleScientific reports2025
Assessing the link between cerebellar volume and cognitive function in Alzheimer's disease: a pilot study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Quantifying Dexterity and Grip Strength Associations between Age, Cognitive Function (MoCA), and Cerebellar Gray Matter Volume in Healthy Adults across the Adult Lifespan.Research square · 2026Article
- Interferon-induced protein IFIT3 as a molecular nexus of neuroinflammation in Alzheimer's disease and HIV-associated neurocognitive disorders.Journal of neuroinflammation · 2026Article
- Cerebellar volumes' selective association with MoCA over MMSE: a diagnostic insight into mild cognitive impairment and mild dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Cerebellar structure is abnormal in schizophrenia and deviates from bipolar disorder.NeuroImage. Clinical · 2026Article
- Developing a QSPR model for Alzheimer's drugs using topological indices and M-polynomial: A computational study.Scientific reports · 2025Article
- Artificial intelligence in neuro-oncology: Current advances and legal considerations in the European Union.Neuro-oncology advancesReview
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Authors and funding
12 authors.
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Abstract
The cerebellum, long recognized for its role in motor functions, has become increasingly acknowledged for its involvement in a broader spectrum of cognitive functions. Given the cerebellum's strong neuronal connections with cerebral regions affected by neurodegenerative diseases, this study investigated the cerebellar contribution to cognitive decline in Alzheimer's disease (AD). This study retrospectively analysed 127 individuals with subjective cognitive decline (SCD, n = 46), mild cognitive impairment due to AD (MCI, n = 24), and AD dementia (ADD, n = 57). Grey and white matter volumes of the whole cerebellum and its lobules were examined and correlated with cognitive scores. Significant grey matter atrophy was observed in posterior cerebellar regions (including crus II, lobule VIIa, VIIIa, VIIIb, and X), particularly between SCD and ADD, but not between MCI and ADD. Additionally, cerebellar volume positively correlated with cognitive function in SCD, MCI and ADD. These findings support the hypothesis that cerebellar atrophy is associated with cognitive symptoms of neurodegenerative diseases like AD.
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