ArticleScientific reports2025
Antimicrobial, synergistic and antibiofilm activities of Myristica fragrans Houtt. Bioactive compounds and their derivatives.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- 6-Aminoflavone Inhibits Planktonic Growth, Disrupts Biofilm Architecture, and Regulates Quorum Sensing inBiochemistry research international · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the antimicrobial efficacy, synergistic interactions, antibiofilm activity, molecular docking studies, and drug-likeness properties of α-terpineol, 4-carvomenthenol, and their derivatives isolated from nutmeg and mace (Myristica fragrans Houtt.). α-Terpineol and 4-carvomenthenol were isolated from nutmeg essential oil and mace oleoresin respectively using column chromatography. Derivatization of α-Terpineol was derivatized into its ester, epoxide, ether, and allylic bromide while 4-carvomenthenol was derivatized to form its ester and epoxide. The antimicrobial activity of isolated compounds and their derivatives was assessed against Bacillus sp., Staphylococcus aureus, Yersinia enterocolitica and Escherichia coli followed by testing of their synergistic interactions with streptomycin. Additionally, the antibiofilm activity of the most effective treatments alone and in combination with was tested in combination with streptomycin was also evaluated. Molecular docking studies were conducted to assess binding affinities of the most effective treatments for DNA gyrase and transpeptidase followed byADMET profiling to evaluate their drug-likeness. The ester derivatives of α-terpineol and 4-carvomenthenol demonstrated the highest antibacterial potential with MIC values ranging from 40 to 170 µg/ml. Both the ester derivatives showed significant synergistic interactions with streptomycin and exhibited strong to intermediate antibiofilm activity against all the tested bacteria. Molecular docking studies indicated favorable binding affinities (-6.56 to - 4.31 kcal/mol) of ester derivatives for DNA gyrase and transpeptidase as compared to their parent compounds having favorable physicochemical properties, meeting drug-likeness criteria. α-Terpineol ester and 4-carvomenthenol ester exhibited promising antimicrobial potential, synergistic interaction with streptomycin and antibiofilm properties, suggesting their potential as novel therapeutic agents. Further development and investigation of these compounds are warranted to explore their applications in clinical settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.