ArticleNPJ Parkinson's disease2025
Sleep stage mixing is associated with poor prognosis in early Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Fully-automated sleep staging for Parkinson's disease and isolated REM sleep behavior disorder.NPJ digital medicine · 2026Article
- Cyclic Alternating Pattern and Sleep Microstructure in Parkinson's Disease: A Systematic Review and Meta-Analysis.Nature and science of sleep · 2026Review
- Automated EEG-based sleep staging in REM sleep behavior disorder using MSIF-Net: epoch-level validation and whole-night clinical agreement.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study assessed the prognostic value of probabilistic sleep staging in early PD by quantifying sleep stage uncertainty and mixing. Data from two longitudinal cohorts (DeNoPa and ICEBERG) included 280 patients with early PD (mean duration 21.1 months) and 158 matched controls. Sleep stages were scored automatically using U-Sleep, which provides for each 30-s epoch a probabilistic distribution of wakefulness (W), NREM stage N1, N2, N3, and REM sleep. Uncertainty (percentage of sleep stages with less than 80% certainty) and mixed stages were quantified. PD patients showed higher sleep stage uncertainty and wake-N3 mixing, especially those with REM sleep behavior disorder. Greater W-N3 mixing was associated with worse motor and cognitive scores at baseline and with faster motor decline over time. EEG features of this mixing suggested unstable deep sleep. These findings support the value of automated sleep analysis to detect microstructural sleep disruptions linked to PD progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.