Evidence map›Paper›PMID 41006244›Full record

ArticleNature communications2025

A single residue in the yellow fever virus envelope protein modulates virion architecture and antigenicity.

Summa Bibby, James Jung, Yu Shang Low, Alberto A Amarilla, Natalee D Newton, Connor A P Scott, Jessica Balk, Yi Tian Ting, Morgan E Freney, Benjamin Liang and 7 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Summa Bibby *School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0002-5747-7657
James Jung *School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0001-6830-8165
Yu Shang LowSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0001-9583-0282
Alberto A AmarillaSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0002-6640-3377
Natalee D NewtonSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0002-5617-8639
Connor A P ScottSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0001-9535-1863
Jessica BalkDepartment of Biochemistry and Molecular Biology and Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID http://orcid.org/0009-0007-6985-9939
Yi Tian TingDepartment of Biochemistry and Molecular Biology and Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Morgan E FreneySchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Benjamin LiangSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0003-3304-4715
Timothy GrantJohn and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI, USA.ORCID http://orcid.org/0000-0002-4855-8703
Fasséli CoulibalyDepartment of Biochemistry and Molecular Biology and Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID http://orcid.org/0000-0003-3380-2117
Paul YoungSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Roy A HallSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Jody Hobson-PetersSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0003-0139-9829
Naphak Modhiran *School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia. n.modhiran@uq.edu.au.ORCID http://orcid.org/0000-0003-3205-4970
Daniel Watterson *School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia. d.watterson@uq.edu.au.ORCID http://orcid.org/0000-0001-5957-2853

Funding

Department of Health | National Health and Medical Research Council (NHMRC) APP1164216Department of Health | National Health and Medical Research Council (NHMRC) APP2004582
6 · The paper itself

Abstract

Yellow fever virus (YFV) is a re-emerging flavivirus that causes severe hepatic disease and mortality in humans. Despite being researched for over a century, the structure of YFV has remained elusive. Here we use a chimeric virus platform to resolve the first high resolution cryo-EM structures of YFV. Stark differences in particle morphology and homogeneity are observed between vaccine and virulent strains of YFV, and these are found to have significant implications on antibody recognition and neutralisation. We identify a single residue (R380) in the YFV

Indexed as

Viral Envelope ProteinsVirionYellow fever virusAnimalsAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCross ReactionsCryoelectron MicroscopyEpitopesHumansYellow FeverYellow Fever VaccineAntibodies, NeutralizingAntibodies, ViralAntigens, ViralEpitopesViral Envelope ProteinsYellow Fever Vaccine

Identifiers

PMID41006244
PMCPMC12475062

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.