Evidence map›Paper›PMID 41006062›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Tonic GABA and Glycine Inhibition Control Pain Hypersensitivity via Limiting α2δ-1- and mGluR5-Dependent NMDA Receptor Activity at Primary Afferent→Excitatory Neuron Synapses.

Yuying Huang 黄玉莹, Hong Chen 陈红, Shao-Rui Chen 陈少瑞, Hui-Lin Pan 潘惠麟

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuying Huang 黄玉莹Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Hong Chen 陈红Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Shao-Rui Chen 陈少瑞Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Hui-Lin Pan 潘惠麟Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.ORCID 0000-0001-8444-3770

Funding

Molecular Determinants of Synaptic Plasticity in Chronic PainR01NS101880 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shao-Rui Chen, Hui-Lin Pan · 2017 to 2026
$4.1M
Neuronal Plasticity and Signaling in Neuropathic PainR01NS073935 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAN, HUI-LIN · 2011 to 2015
$1.8M
NINDS NIH HHS R01 NS073935NINDS NIH HHS R01 NS101880
6 · The paper itself

Abstract

Impaired synaptic inhibition by GABA and glycine contributes to excitatory-inhibitory imbalance in the spinal cord associated with chronic neuropathic pain; however, the underlying mechanisms remain unclear. Here, we investigated how GABAergic and glycinergic inputs regulate synaptic

Indexed as

gamma-Aminobutyric AcidGlycineHyperalgesiaNeurons, AfferentReceptor, Metabotropic Glutamate 5Receptors, N-Methyl-D-AspartateSynapsesAnimalsCalcium ChannelsExcitatory Postsynaptic PotentialsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutCACNA2D1 protein, mouseCalcium Channelsgamma-Aminobutyric AcidGlycineGrm5 protein, mouseReceptor, Metabotropic Glutamate 5Receptors, N-Methyl-D-Aspartatedorsal root gangliongabapentinoidK+-Cl− cotransporter 2 (KCC2)neuropathic painsynaptic plasticityvesicular inhibitory amino acid transporter (VIAAT)

Identifiers

PMID41006062
PMCPMC12572926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.