Observational studyThe Journal of international medical research2025
Serum histamine in non-small cell lung cancer: An observational study in the context of allergo-oncology.
Observational study in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Review
- Integrated Network Toxicology and Metabolomics Elucidate Mechanisms of Carbosulfan-Induced Respiratory Toxicity in Rats.International journal of molecular sciences · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectivesThe objective of this study was to assess serum histamine levels in patients with non-small cell lung cancer and investigate their association with tumor metastasis.MethodsA retrospective study was conducted at Lu'an Hospital between 2020 and 2024, including 90 patients (70 with non-small cell lung cancer and 20 with benign pulmonary nodules) selected from an initial cohort of 416 patients after applying strict inclusion and exclusion criteria. Serum histamine levels were measured, and other clinical characteristics and laboratory parameters were obtained directly from the electronic medical record system. Receiver operating characteristic curves were used to evaluate the diagnostic performance. Non-small cell lung cancer patients were stratified by metastatic status for group comparisons and logistic regression analyses.ResultsNon-small cell lung cancer patients had significantly higher serum histamine levels than those with benign nodules (median: 8.58 vs. 5.97 µg/L, p = 0.024). A cutoff of 7 µg/L yielded a sensitivity of 65.7% and a specificity of 65.0% for distinguishing non-small cell lung cancer, with an area under the curve of 0.666. Among non-small cell lung cancer patients, those with metastasis (
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