Evidence map›Paper›PMID 41005745›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2025

Enhanced safety and potency in local angiogenic growth factor delivery via aptamer functionalization of hydrogels.

Connie Wen, Ji Ho Park, Neekita R Jikaria, Mary E Landmesser, Jazzmyn Dawes, Chien-Wei Wu, Dino Ravnic, Yong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Connie WenDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
Ji Ho ParkIrvin Zubar Plastic Surgery Research Laboratory, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Neekita R JikariaIrvin Zubar Plastic Surgery Research Laboratory, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Mary E LandmesserIrvin Zubar Plastic Surgery Research Laboratory, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Jazzmyn DawesIrvin Zubar Plastic Surgery Research Laboratory, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Chien-Wei WuDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
Dino RavnicIrvin Zubar Plastic Surgery Research Laboratory, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Yong WangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: yxw30@psu.edu.

Funding

Non-covalent functionalization of collagen for growth factor delivery using bispecific aptamersR01EB035568 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Yong Wang · 2024 to 2026
$1.3M
NIBIB NIH HHS R01 EB035568
6 · The paper itself

Abstract

Hydrogels for drug delivery, particularly for the delivery of potent protein therapeutics, have been extensively studied across various biomedical applications. Because hydrogels act as reservoirs for localized drug release, this delivery approach is generally not expected to cause the same severe systemic toxicity observed with systemic drug administration. However, the current study has shown for the first time that the implantation of native hydrogels loaded with vascular endothelial growth factor (VEGF) induced acute severe hemorrhage and animal mortality in a femoral vessel micropuncture (MP) surgery model. In contrast, no side effects were observed when hydrogels functionalized with anti-VEGF aptamers and loaded with the same amount of VEGF were implanted. Furthermore, the presence of the aptamers in the hydrogels did not compromise the ability of VEGF to promote new blood vessel growth.

Indexed as

Angiogenesis Inducing AgentsAptamers, NucleotideHydrogelsVascular Endothelial Growth Factor AAnimalsDrug Delivery SystemsHemorrhageHumansMaleMiceNeovascularization, PhysiologicAngiogenesis Inducing AgentsAptamers, NucleotideHydrogelsVascular Endothelial Growth Factor AAngiogenesisAptamerGrowth factor releaseHydrogelMicropuncture

Identifiers

PMID41005745
PMCPMC12498206

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.