Evidence map›Paper›PMID 41005664›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2026

Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence.

Lucy Vanes, Divyangana Rakesh, Tobias Banaschewski, Arun L W Bokde, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz and 16 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Lucy VanesDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. Electronic address: lucy.vanes@kcl.ac.uk.
Divyangana RakeshDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, and German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine, and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Penny GowlandSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Antoine GrigisNeuroSpin, Commissariat à l'Énergie Atomique et aux Energies Alternatives, Université Paris-Saclay, Gif-sur-Yvette, France.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, University of Tübingen, and German Center for Mental Health (DZPG), partner site Tübingen, Tübingen, Germany.
Herve LemaitreNeuroSpin, Commissariat à l'Énergie Atomique et aux Energies Alternatives, Université Paris-Saclay, Gif-sur-Yvette, France; Institut des Maladies Neurodégénératives, Unité Mixte de Recherche 5293, Centre National de la Recherche Scientifique, Commissariat à l'Énergie Atomique et aux Energies Alternatives, Université de Bordeaux, Bordeaux, France.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale U A10 "Trajectoires Développementales & Psychiatrie, " University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Centre Borelli, Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale U A10 "Trajectoires Développementales & Psychiatrie, " University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Centre Borelli, Gif-sur-Yvette, France; L'Assistance Publique-Hôpitaux de Paris, Sorbonne Université, and Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale U A10 "Trajectoires Développementales & Psychiatrie, " University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Centre Borelli, Gif-sur-Yvette, France; Psychiatry Department, Etablissement Public de Santé Barthélémy Durand, Etampes, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, and German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, Germany; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
Dimitri Papadopoulos OrfanosDepartment of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Luise PoustkaDepartment of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, and German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, and German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, Germany.
Nilakshi VaidyaCentre for Population Neuroscience and Medicine Precision, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Gunter SchumannCentre for Population Neuroscience and Medicine Precision, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany; Centre for Population Neuroscience and Medicine Precision, Institute for Science and Technology of Brain-inspired Intelligence, Fudan University, Shanghai, China.
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
IMAGEN Consortium

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238Wellcome Trust
6 · The paper itself

Abstract

backgroundAdolescence is a critical period of neurodevelopment marked by ongoing maturation of structural and functional brain connectivity. Simultaneously, this period is associated with an increase in mental health problems, spanning from subclinical symptoms to diagnosable disorders.

methodsThis study investigated longitudinal associations between psychopathology dimensions and voxelwise brain measures related to connectivity across 3 time points (ages 14, 19, and 23) in more than 1500 participants using the IMAGEN dataset. White matter (WM) microstructure was indexed using diffusion metrics quantified along the WM skeleton (N = 1736), while functional connectivity was captured as voxelwise degree centrality (DC) derived from resting-state functional imaging (N = 1510).

resultsDevelopment of WM microstructure was selectively linked to externalizing (but not internalizing) symptoms. Here, higher externalizing symptoms were associated with widespread reductions in fractional anisotropy (FA) across the WM skeleton as well as accelerated decreases in FA in the corticospinal tract over time. In contrast, functional DC was developmentally associated with general, rather than specific, psychopathology in frontal and temporal regions. An increase in total difficulties over time was associated with developmental decrease in DC in bilateral superior frontal gyri. In addition, a positive association between total difficulties and DC in left inferior temporal gyrus was observed in younger, but not older, adolescents or young adults.

conclusionsThese findings highlight the dynamic interplay between brain connectivity development and psychopathology in adolescence, with potential implications for identifying neural markers of risk and resilience during sensitive windows of development.

Indexed as

BrainConnectomeMental DisordersNerve NetWhite MatterAdolescentDiffusion Tensor ImagingFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleNeural PathwaysNeurodevelopmentYoung AdultAdolescenceExternalizingFunctional connectivityInternalizingStructural connectivity

Identifiers

PMID41005664
PMCPMC13646494

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