Evidence map›Paper›PMID 41005369›Full record

ReviewSeminars in respiratory and critical care medicine2025

Emerging Concepts in Pathogenesis, Multiomics Applications, and Clinical Research in Lymphangioleiomyomatosis.

Jane J Yu, Nishant Gupta, Minzhe Guo, Tasnim Olatoke, Yan Xu

Abstract readReview
In one paragraph

Review in Seminars in respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jane J YuDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Nishant GuptaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Minzhe GuoThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Tasnim OlatokeDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Yan XuThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Funding

LungMap Phase II - Building a multidimensional map of developing human lungU01HL148856 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A, XU, YAN · 2019 to 2023
$4.5M
Uterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM)R01HL153045 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI XU, YAN, YU, JANE · 2020 to 2023
$3.1M
A mechanistic 3D AI-powered map of genetic chILDU01HL175383 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Jichao Chen, Kathryn Ann Wikenheiser-Brokamp · 2024 to 2026
$2.4M
Cellular determinants of responsiveness to mTOR inhibitors in LAMR01HL172914 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI YAN XU, Jane Yu · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL153045NHLBI NIH HHS R01 HL172914NHLBI NIH HHS U01 HL148856NHLBI NIH HHS U01 HL175383
6 · The paper itself

Abstract

Lymphangioleiomyomatosis (LAM) is a rare, female-predominant, low-grade neoplasm characterized by infiltration of abnormal smooth muscle-like and epithelioid cells into the lung parenchyma, leading to cystic changes and progressive respiratory failure. In recent years, LAM has been an exemplar of meaningful progress in a rare lung disease, driven by close collaboration between patients, scientists, and clinicians, leading to the development of the U.S. Food and Drug Administration (FDA)-approved therapy, a diagnostic biomarker, a worldwide clinic network, and clinical practice guidelines. Integrating state-of-the-art bioinformatics and experimental approaches is helping accelerate the scientific progress in LAM and promises the development of novel biomarkers and therapies in the coming few years.

Indexed as

Lung NeoplasmsLymphangioleiomyomatosisBiomarkersComputational BiologyFemaleHumansMultiomicsBiomarkers

Identifiers

PMID41005369
PMCPMC13679379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.