ArticleStem cell reports2025
A proper excitatory/inhibitory ratio is required to develop synchronized network activity in mouse cortical cultures.
Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Establishing mouse forebrain organoids as models of intrinsic cortical network assembly.Stem cell reports · 2026Article
- Focal cortical dysplasias: modeling pediatric drug-resistant epilepsy using human brain organoids.Frontiers in cellular neuroscience · 2026Review
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9 authors.
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Abstract
Excitatory/inhibitory (E/I) balance is thought to play a key role in cortical activity development. We modeled an in vitro cortical network deployed of the inhibitory neurons normally migrating from the ventral telencephalon and implemented ventral telencephalic (VT) cultures and co-cultures with mixed proportions of dorsal telencephalic (DT) and VT neurons, containing distinct proportions of inhibitory neurons. Interestingly, these pure and mixed cultures developed different patterns of spontaneous activity and functional connectivity. Our findings highlighted a critical role for the inhibitory component in developing correlated network activity. Unexpectedly, networks with 7% of parvalbumin (PV)
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