Evidence map›Paper›PMID 41005294›Full record

ArticleImmunity2025

S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis.

Mrinmoy Das, Mohammed Alasharee, Brian Woods, Saikat Mukherjee, Shira Kim, Megan Elkins, Jacqueline Ngo, Logan Magin, Maheshwor Timilshina, Juan Manuel Leyva-Castillo and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Basophils in atopic dermatitis: Immunologic roles and clinical implications.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Review
  4. Review
  5. RespiratoryFrontiers in immunology · 2026
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Mrinmoy DasDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Division of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, India. Electronic address: mdasmicro@gmail.com.
Mohammed AlashareeDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Brian WoodsDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Saikat MukherjeeDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Shira KimDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Megan ElkinsDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Jacqueline NgoDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Logan MaginDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Maheshwor TimilshinaDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Juan Manuel Leyva-CastilloDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Robert M AnthonyDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ana Flávia Santarine LaureanoDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
George F MurphyDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shannon McNameeDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Frank BrombacherUniversity of Cape Town, Cape Town, South Africa.
Simon P HoganDepartment of Pathology University of Michigan, Ann Arbor, MI, USA.
Jerrold R TurnerDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Shabnam AbtahiDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Wanda PhipatanakulDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Donald Y M LeungDepartment of Pediatrics, National Jewish Health, Denver, CO, USA.
Elena GolevaDepartment of Pediatrics, National Jewish Health, Denver, CO, USA.
Hans C OettgenDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Mei LiCentre National de la Recherche Scientifique, Université de Strasbourg, Illkirch, France.
Janet ChouDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Patrick M SchlievertDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Fred D FinkelmanDivision of Immunobiology, Department of Pediatrics, Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Raif S GehaDivision of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address: raif.geha@childrens.harvard.edu.

Funding

Experimental and Computational Analysis of the Human Epidemiology and Response to SARS-CoV-2 (HEROS) CohortUM1AI151958 · NIAID · NATIONAL JEWISH HEALTH · PI Donald YM Leung · 2020 to 2026
$38.3M
ZO-1-MEDIATED PROTEIN INTERACTIONS: REGULATORS AND INTEGRATORS OF DIVERSE EPITHELIAL FUNCTIONS IN HEALTH AND DISEASER01DK061931 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2001 to 2026
$15.0M
Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.R01DK068271 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2005 to 2026
$11.3M
Mast cell regulation of Th2 induction and tolerance breakdown in food allergyR01AI119918 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI OETTGEN, HANS C · 2015 to 2025
$5.6M
Genetic and microbial modifiers of Atopic Dermatitis (AD): Mechanisms of increased AD severity in patients with the R576 polymorphism in IL-4Ra and impact of S aureus skin decolonization on ADU01AI152033 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI RAIF SALIM GEHA, WANDA PHIPATANAKUL · 2020 to 2026
$3.7M
Mechanisms of enhanced food allergy by S. aureus skin colonization in Atopic DermatitisR01AI175556 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI RAIF SALIM GEHA · 2023 to 2026
$3.1M
NIAID NIH HHS R01 AI119918NIAID NIH HHS R01 AI175556NIAID NIH HHS U01 AI152033NIAID NIH HHS UM1 AI151958NIDDK NIH HHS R01 DK061931NIDDK NIH HHS R01 DK068271
6 · The paper itself

Abstract

The mechanism of the association of S. aureus skin colonization with food allergy in atopic dermatitis (AD) is unknown. Interleukin-4 (IL-4) plays an important role in food allergy. We found elevated serum IL-4 concentrations in AD patients with S. aureus skin colonization and food allergy. Using an AD mouse model, we demonstrated that epicutaneous application of antigen together with superantigen-producing S. aureus, or staphylococcal enterotoxin B (SEB), caused a heightened systemic antigen-specific T helper-2 (Th2) response and elevated serum IL-4 concentrations. T cell-derived IL-4 acted on intestinal epithelial cells to enhance intestinal permeability and anaphylaxis to enteral antigen challenge. CD40-dependent SEB binding to keratinocytes triggered IL-33 release, which caused T cells to produce IL-3 that elicited a basophil influx in skin-draining lymph nodes (dLNs). Basophil-derived IL-4 augmented Th2 cell polarization by antigen-bearing dendritic cells from skin dLNs. These results suggest therapeutic interventions that might attenuate food allergy in AD patients.

Indexed as

AnaphylaxisBasophilsDermatitis, AtopicFood HypersensitivityInterleukin-4SkinStaphylococcus aureusAnimalsAntigens, BacterialDendritic CellsDisease Models, AnimalEnterotoxinsFemaleHumansInterleukin-33MaleAntigens, Bacterialenterotoxin B, staphylococcalEnterotoxinsInterleukin-33Interleukin-4Superantigensatopic dermatitisbasophilfood allergyIL-4intestinal epithelial cellintestinal permeabilityS. aureus

Identifiers

PMID41005294
PMCPMC12805839

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.