Evidence map›Paper›PMID 41004702›Full record

Observational studyJCO precision oncology2025

Leveraging Real-World Data From a Clinicogenomic Database Addresses the Treatment Gap in Patients With High-Grade Serous Ovarian Cancer.

Chiara Maura Ciniselli, Elena Conca, Michele Bartoletti, Nicoletta Colombo, Umberto Malapelle, Salvatore Lopez, Sandro Pignata, Francesco Raspagliesi, Paolo Verderio, Claudio Zamagni and 6 more

Abstract readObservational Study
In one paragraph

Observational study in JCO precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chiara Maura CiniselliUnit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0003-4488-885X
Elena ConcaDepartment of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0003-2052-8104
Michele BartolettiUnit of Medical Oncology and Cancer Prevention, Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.ORCID 0000-0002-9631-5693
Nicoletta ColomboDepartment of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.ORCID 0000-0003-2225-715X
Umberto MalapelleDepartment of Public Health, University Federico II of Naples, Naples, Italy.ORCID 0000-0003-3211-9957
Salvatore LopezGynecologic Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
Sandro PignataUro-Gynecological Medical Oncology, Istituto Nazionale Tumori, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione G Pascale, Naples, Italy.
Francesco RaspagliesiGynecological Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Paolo VerderioUnit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0002-9231-1281
Claudio ZamagniIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.ORCID 0000-0002-7143-9091
Valentina Sara BarbieroRoche Pharma, Monza, Italy.
Silvia CastellaniRoche Pharma, Monza, Italy.
Emilia SicariRoche Pharma, Monza, Italy.ORCID 0009-0002-9010-3005
Luca AgnelliDepartment of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0003-0582-6170
Federica PerroneDepartment of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0003-4406-8245
Giancarlo PruneriDepartment of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0002-7963-7172

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study used a deidentified nationwide (US-based) high-grade serous ovarian cancer (HGSOC) clinicogenomic database (CGDB) to enrich our understanding of HGSOC's genomic heterogeneity and assess the utility of comprehensive genomic profiling (CGP) in clinical settings. PATIENTS AND

methodsWe conducted a retrospective observational analysis on 856 patients with HGSOC profiled with CGP genomic tests, retrieved from CGDB from January 2011 to September 2023.

resultsIn addition to

conclusionOverall, our study provides evidence that CGP significantly improves the identification of molecular targets in HGSOC, supporting its importance in the clinical practice to provide patients with more therapeutic options.

Indexed as

Cystadenocarcinoma, SerousOvarian NeoplasmsAdultAgedAged, 80 and overFemaleHumansMiddle AgedMutationRetrospective Studies

Identifiers

PMID41004702
PMCPMC12502943

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.