Evidence map›Paper›PMID 41004642›Full record

ArticleInternational journal of social determinants of health and health services2026

Reframing the Overdose Crisis: Stigma, Industry Influence, and the Politics of Abuse-Deterrent Opioids.

Daniel Eisenkraft Klein, Quinn Grundy, Benjamin Hawkins, Robert Schwartz

Abstract read
In one paragraph

Article in International journal of social determinants of health and health services, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel Eisenkraft KleinDalla Lana School of Public Health, University of Toronto, Toronto, Canada.ORCID 0000-0002-9451-9668
Quinn GrundyLawrence Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada.
Benjamin HawkinsMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7027-8046
Robert SchwartzDalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Between 2013 and 2017, Canadian federal policymakers grappled with mandating abuse-deterrent formulations (ADFs) for oxycodone products as a response to the overdose crisis. Marketed as a safeguard against misuse and diversion, ADFs promised a technological fix to opioid-related harms, yet their population-level effectiveness remained contested. This study systematically analyzes federal parliamentary debates and committee hearings, identifying key arguments in framings to support or oppose ADF mandates. Proponents framed the crisis through the lens of individual misuse, positioning ADFs as pharmaceutical safeguards that protected "legitimate" patients while curbing illicit opioid use. Opponents challenged ADFs' effectiveness, highlighted Purdue Pharma's role in the crisis, and warned of unintended consequences, including shifts to more dangerous illicit markets. These discursive struggles reinforced a bifurcation between "legitimate" and "illegitimate" opioid use, shaping perceptions of responsibility, medical necessity, and the scope of appropriate intervention. Divergent framings reflected deeper ideological fissures over the etiology of the overdose crisis and who should be considered a justifiable opioid patient. By demonstrating how ADF debates entrenched a dichotomy between acceptable and unacceptable opioid use, this study advances theories of problem framing to demonstrate how policy debates actively shape regulatory paradigms and the boundaries of acceptable government intervention.

Indexed as

Abuse-Deterrent FormulationsAnalgesics, OpioidDrug IndustryDrug OverdoseOpiate OverdoseOpioid-Related DisordersPoliticsSocial StigmaCanadaHumansOxycodoneAbuse-Deterrent FormulationsAnalgesics, OpioidOxycodoneabuse-deterrent opioidsopioid crisisopioid industryopioidsoverdose crisisoxycontinpolicy framingstigma

Identifiers

PMID41004642
PMCPMC12662823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.