Evidence map›Paper›PMID 41004596›Full record

ArticleScience advances2025

Human precursor T follicular regulatory cells are primed for differentiation into mature Tfr and disrupted during severe infections.

Janyerkye Tulyeu, Jonas N Søndergaard, David G Priest, Takeshi Ebihara, Hisatake Matsumoto, Mara A Llamas-Covarrubias, Masaki Imai, Shinichi Esaki, Shinichi Iwasaki, Akimichi Morita and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Janyerkye TulyeuHuman Single Cell Immunology Team, CiDER, The University of Osaka, Osaka, Japan.ORCID 0000-0003-1473-5561
Jonas N SøndergaardHuman Single Cell Immunology Team, CiDER, The University of Osaka, Osaka, Japan.ORCID 0000-0002-4438-6756
David G PriestLaboratory of Human Single Cell Immunology, IFReC, The University of Osaka, Osaka, Japan.ORCID 0000-0003-0095-6718
Takeshi EbiharaDepartment of Traumatology and Acute Critical Medicine, The University of Osaka Graduate School of Medicine, Osaka, Japan.ORCID 0000-0003-4101-0419
Hisatake MatsumotoDepartment of Traumatology and Acute Critical Medicine, The University of Osaka Graduate School of Medicine, Osaka, Japan.
Mara A Llamas-CovarrubiasLaboratory of Human Single Cell Immunology, IFReC, The University of Osaka, Osaka, Japan.ORCID 0000-0001-6059-673X
Masaki ImaiDepartment of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.ORCID 0000-0001-5405-0837
Shinichi EsakiDepartment of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.ORCID 0000-0001-8784-3964
Shinichi IwasakiDepartment of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Akimichi MoritaDepartment of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.ORCID 0000-0001-8372-3754
Sayuri YamazakiDepartment of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Shimon SakaguchiLaboratory of Experimental Immunology IFReC, The University of Osaka, Osaka, Japan.ORCID 0000-0001-8265-6094
James B WingHuman Single Cell Immunology Team, CiDER, The University of Osaka, Osaka, Japan.ORCID 0000-0002-3462-1003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T follicular regulatory cells (Tfr) play a pivotal role in maintaining immune self-tolerance and prevention of autoantibody induction. However, the stages of Tfr formation have still not been clarified. Here, we found that 30 to 50% of circulating Tfr in human blood have a naïve-like phenotype (preTfr, CD45RA

Indexed as

Cell DifferentiationCOVID-19T-Lymphocytes, RegulatoryB-LymphocytesFemaleHumansInterferon-gammaMaleMiddle AgedSARS-CoV-2Interferon-gamma

Identifiers

PMID41004596
PMCPMC12467056

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.