Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Hanlin ZhangDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-9353-6071
C Kimberly TsuiDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3807-5329
Jesse Garcia CastilloDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-5786-7914
Esther Jeong Yoon KimDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-4436-3826
Audrey EvangelistaDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
HengChen LiuDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0007-7426-3275
Larry K JoeDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0000-0016-7554
Nicholas TwellsDepartment of Chemistry, University of Alberta, Edmonton, T6G 2G2, Canada.
Ellen A RobeyDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3630-5266
Lara K MahalDepartment of Chemistry, University of Alberta, Edmonton, T6G 2G2, Canada.ORCID 0000-0003-4791-8524
Michel DuPageDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-1479-9840
Andrew DillinDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-7427-2629
Funding
Neuroendocrine Coordination of Mitochondrial Stress Signaling and ProteostasisR01ES021667 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2012 to 2023
$4.6M
The Perception of Mitochondrial Stress in Receiving CellsR37AG024365 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2011 to 2020
$4.0M
Extracellular Matrix Control of Mitochondrial Homeostasis and LongevityR01AG082797 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Andrew G Dillin · 2023 to 2026
$1.5M
Systemic Regulation of ER ProteostasisF32AG069388 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI TSUI, CHUNG YIN KIMBERLY · 2021 to 2023
Glycans regulate cellular function, yet how aging affects the glycocalyx remains unclear. Here, we investigate changes in immune cell glycocalyx with age and find that α2,6-linked sialic acid, a glycan epitope associated with inhibitory signaling, is down-regulated in T cells from old animals. This reduction is tightly correlated with age-associated accumulation of effector T cells, which have little to no α2,6-linked sialic acid. To understand how α2,6-linked sialic acid affects T cell physiology, we generated a mouse model with T cell-specific deletion of sialyltransferase gene
Indexed as
AgingCD8-Positive T-LymphocytesAnimalsbeta-D-Galactoside alpha 2-6-SialyltransferaseListeria monocytogenesListeriosisMiceMice, Inbred C57BLMice, KnockoutN-Acetylneuraminic AcidPolysaccharidesProgrammed Cell Death 1 ReceptorSialyltransferasesbeta-D-Galactoside alpha 2-6-SialyltransferaseN-Acetylneuraminic AcidPolysaccharidesProgrammed Cell Death 1 ReceptorSialyltransferases
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Age-related remodeling of the sialoglycans dampens murine CD8 · full record | OpenQuestion