Evidence map›Paper›PMID 41004589›Full record

ArticleScience advances2025

AggreBots: Configuring CiliaBots through guided, modular tissue aggregation.

Dhruv Bhattaram, Kian Golestan, Xuanshuo Zhang, Shihong Yang, Zhuowei Gong, Steven L Brody, Amjad Horani, Victoria A Webster-Wood, Amir Barati Farimani, Xi Ren

Abstract read
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In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Dhruv BhattaramDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0002-1002-5506
Kian GolestanDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0009-0005-6833-8969
Xuanshuo ZhangDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0009-0002-1014-1280
Shihong YangDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0009-0000-7915-8991
Zhuowei GongDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0002-7579-9262
Steven L BrodyDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0905-7527
Amjad HoraniDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5352-1948
Victoria A Webster-WoodDepartment of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0001-6638-2687
Amir Barati FarimaniDepartment of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Xi RenDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0003-3187-1311

Funding

Expedited Assessment of Environment-induced Respiratory Ciliopathies Leveraging Motile Apical-out Airway OrganoidsF31HL176100 · NHLBI · CARNEGIE-MELLON UNIVERSITY · PI Dhruv Bhattaram · 2024 to 2026
$99k
NHLBI NIH HHS F31 HL176100
6 · The paper itself

Abstract

Ciliated biobots (CiliaBots) are engineered tissues capable of self-actuated propulsion via exterior motile cilia. While correlations have been observed between CiliaBot motility and morphology, direct control of morphological features to deliver desired motility outcomes remains unexplored. Here, we describe the engineering of aggregated CiliaBots (AggreBots) to augment control over CiliaBot structural parameters and, consequently, motility patterns through guided, modular aggregation of human airway epithelial spheroids [referred to as CiliaBot building blocks (CBBs)]. Multi-CBB aggregation generated rod-, triangle-, and diamond-shaped AggreBots, altering tissue geometry without sacrificing surface cilia density or inter-CBB boundary fidelity. The further introduction of

Indexed as

CiliaSpheroids, CellularTissue EngineeringEpithelial CellsHumans

Identifiers

PMID41004589
PMCPMC12467051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.