Evidence map›Paper›PMID 41004575›Full record

ArticleScience advances2025

TOC1 phosphorylation disproportionally enhances chromatin binding at rhythmic gene promoters.

Jiapei Yan, Ying Zhang, Guoting Chen, Cuilin Gui, Zhangli Tu, Donglin Cao, Jing-Wen Yao, Xingwang Li, David E Somers

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. ThePlants (Basel, Switzerland) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiapei YanDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-2573-2702
Ying ZhangNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, Hubei, China.ORCID 0009-0002-7892-6869
Guoting ChenNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, Hubei, China.ORCID 0009-0004-3455-6143
Cuilin GuiNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Zhangli TuNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Donglin CaoNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Jing-Wen YaoDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-8510-7381
Xingwang LiNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, Hubei, China.ORCID 0000-0003-3985-2545
David E SomersDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-5170-2430

Funding

Post-translational control mechanisms of the circadian clockR01GM093285 · NIGMS · OHIO STATE UNIVERSITY · PI SOMERS, DAVID E · 2010 to 2018
$2.7M
Inter- and intracellular mechanisms of circadian regulationR35GM136400 · NIGMS · OHIO STATE UNIVERSITY · PI SOMERS, DAVID E · 2020 to 2024
$1.9M
NIGMS NIH HHS R01 GM093285NIGMS NIH HHS R35 GM136400
6 · The paper itself

Abstract

Protein phosphorylation is a key regulatory mechanism in circadian systems. TIMING OF CAB EXPRESSION 1 (TOC1) is a core transcriptional repressor in the plant circadian system that is phosphorylated near its N terminus. Phenotype testing of TOC1 phosphosite mutants shows incomplete rescue of the short period

Indexed as

ArabidopsisArabidopsis ProteinsChromatinCircadian RhythmPromoter Regions, GeneticTranscription FactorsBasic Helix-Loop-Helix ProteinsGene Expression Regulation, PlantPhosphorylationProtein BindingArabidopsis ProteinsBasic Helix-Loop-Helix ProteinsCCA1 protein, ArabidopsisChromatinTOC1 protein, ArabidopsisTranscription Factors

Identifiers

PMID41004575
PMCPMC12466851

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.